Evidence map›Paper›PMID 31598642›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Effect of Publicly Reported Aortic Valve Surgery Outcomes on Valve Surgery in Injection Drug- and Non-Injection Drug-Associated Endocarditis.

Simeon D Kimmel, Alexander Y Walley, Benjamin P Linas, Bindu Kalesan, Eric Awtry, Nikola Dobrilovic, Laura White, Marc LaRochelle

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Against Medical Advice Discharges in Injection and Non-injection Drug Use-associated Infective Endocarditis: A Nationwide Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Simeon D KimmelSection of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Alexander Y WalleySection of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Benjamin P LinasSection of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Bindu KalesanBoston University School of Medicine, Boston, Massachusetts, USA.
Eric AwtryBoston University School of Medicine, Boston, Massachusetts, USA.
Nikola DobrilovicBoston University School of Medicine, Boston, Massachusetts, USA.
Laura WhiteDepartment of Biostatistics, Boston University School of Public Health Boston, Massachusetts, USA.
Marc LaRochelleSection of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston, Massachusetts, USA.

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Utilization of health services after engagement with opioid use disorder (OUD) treatment provider by individuals with and without post-traumatic stress disorderP30DA040500 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Benjamin P. Linas · 2015 to 2026
$20.7M
Clinical Addiction Research and Education ProgramR25DA013582 · NIDA · BOSTON MEDICAL CENTER · PI JEFFREY H. SAMET, Alexander Yale Walley · 2001 to 2026
$8.9M
Researching Effective Strategies to Prevent Opioid Death (RESPOND)R01DA046527 · NIDA · BOSTON MEDICAL CENTER · PI Benjamin P. Linas · 2018 to 2026
$7.2M
BU Clinical HIV/AIDS Research Training Program (BU-CHART)T32AI052074 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Benjamin P. Linas · 2003 to 2026
$6.7M
Advancing Clinical Research Training within Addiction Residency ProgramsR25DA033211 · NIDA · BOSTON MEDICAL CENTER · PI Patrick O'Connor, JEFFREY H. SAMET · 2012 to 2026
$4.2M
Improving urine drug test utility to mitigate prescription opioid riskK23DA042168 · NIDA · BOSTON MEDICAL CENTER · PI LAROCHELLE, MARC · 2017 to 2021
$956k
NIAID NIH HHS P30 AI042853NIAID NIH HHS T32 AI052074NIDA NIH HHS K23 DA042168NIDA NIH HHS P30 DA040500NIDA NIH HHS R01 DA046527NIDA NIH HHS R25 DA013582
6 · The paper itself

Abstract

backgroundInjection drug use-associated infective endocarditis (IDU-IE) is rising and valve surgery is frequently indicated. The effect of initiating public outcomes reporting for aortic valve surgery on rates of valve surgery and in-hospital mortality for endocarditis is not known.

methodsFor an interrupted time series analysis, we used data from the National Inpatient Sample, a representative sample of United States inpatient hospitalizations, from January 2010 to September 2015. We included individuals aged 18-65 with an International Classification of Diseases, Ninth Revision (ICD-9) diagnosis of endocarditis. We defined IDU-IE using a validated combination of ICD-9 codes. We used segmented logistic regression to assess for changes in valve replacement and in-hospital mortality rates after the public reporting initiation in January 2013.

resultsWe identified 7322 hospitalizations for IDU-IE and 23 997 for non-IDU-IE in the sample, representing 36 452 national IDU-IE admissions and 119 316 non-IDU admissions, respectively. Following the implementation of public reporting in 2013, relative to baseline trends, the odds of valve replacement decreased by 4.0% per quarter (odds ratio [OR] 0.96, 95% confidence interval [CI] 0.93-0.99), with no difference by IDU status. The odds of an in-patient death decreased by 2.0% per quarter for both IDU-IE and non-IDU-IE cases following reporting (OR 0.98, 95% CI 0.97-0.99).

conclusionsInitiating public reporting was associated with a significant decrease in valve surgery for all IE cases, regardless of IDU status, and a reduction in-hospital mortality for patients with IE. Patients with IE may have less access to surgery as a consequence of public reporting. To understand how reduced valve surgery impacts overall mortality, future studies should examine the postdischarge mortality rate.

Indexed as

EndocarditisPharmaceutical PreparationsAdolescentAdultAftercareAgedAortic ValveHospital MortalityHumansMiddle AgedPatient DischargeRetrospective StudiesUnited StatesYoung AdultPharmaceutical Preparationscardiac surgeryendocarditisinjection drug usepublic reporting

Identifiers

PMID31598642
PMCPMC7384313

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.