ArticleJournal of the Endocrine Society2019
E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed
Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Birth outcomes following intrauterine exposure to electronic nicotine delivery systems: a systematic review and meta-analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Pooled it
- Electronic Cigarettes and Female Reproduction: A Systematic Review of Experimental and Clinical Evidence.International journal of molecular sciences · 2026Pooled it
- Pooled it
- People smoke for nicotine, but lose sexual and reproductive health for tar: a narrative review on the effect of cigarette smoking on male sexuality and reproduction.Journal of endocrinological investigation · 2020Pooled it
- The Effects of E-Cigarette Vapor Components on the Morphology and Function of the Male and Female Reproductive Systems: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- E-cigarette use (vaping) and cigarette smoking are associated with reduced markers of ovarian reserve: a cross-sectional study of 16,087 women.BMC women's health · 2026Article
- Prenatal Cannabis and Tobacco: Studies in Animal Models.Advances in experimental medicine and biology · 2026Review
- Comparative effects of alternate tobacco products and traditional tobacco smoking on various organ/systems: A guide to regulators and health policy makers.Toxicology reports · 2025Review
- Nicotine in e-cigarette aerosol reduces GABA neuron migration via the α7 nicotinic acetylcholine receptor.Scientific reports · 2025Article
- Flavored e-cigarettes modulate embryo development, fetal growth, and potentiate early fetal demise without nicotine.Communications medicine · 2025Article
- Maternal Electronic Cigarette Inhalation Exposure During Gestation: Impacts on Prolactin and Xanthine Oxidase.Cardiovascular toxicology · 2025Article
- Screening for Endocrine Bioactivity Potential of Tobacco Product Chemicals Including Flavor Chemicals.Environmental toxicology · 2025Article
- Impaired implantation as a major upstream pathway of preeclampsia: a narrative synthesis of mechanistic, epidemiological and biomarker evidence.Frontiers in reproductive health · 2025Review
- Intrapartum Electronic Cigarette Use and Birth Outcomes: Evidence from a Population-Based Study.International journal of environmental research and public health · 2024Article
- Fetal Growth Following Electronic Cigarette Use in Pregnancy.International journal of environmental research and public health · 2024Article
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes.The Journal of physiology · 2024Article
- Consumption of hookahs, e-cigarettes, and classic cigarettes and the impact on medically assisted reproduction treatment.Scientific reports · 2024Article
- An Overview of E-Cigarette Impact on Reproductive Health.Life (Basel, Switzerland) · 2023Review
- Prenatal exposure to acrylamide differently affected the sex ratio, aromatase and apoptosis in female adult offspring of two subsequent generations.Physiological research · 2023Article
- In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice.Toxicology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Electronic nicotine delivery system (e-cigarette) use is prevalent among pregnant women as a seemingly safe alternative to traditional tobacco use, known to result in fetal developmental abnormalities and impaired fertility of male offspring. However, little is known about the effects of e-cigarette use on fertility or pregnancy outcomes. A successful pregnancy is initiated by a multitude of dynamic molecular alterations in the uterus resulting in embryo implantation at day 4.5 in the mouse. We examined whether e-cigarette exposure impairs implantation and offspring health. Pregnant C57BL/6J mice were exposed five times a week to e-cigarette vapor or sham. After 4 months, e-cigarette exposed dams exhibited a significant delay in the onset of the first litter. Furthermore, exposure of new dams in early pregnancy significantly impaired embryo implantation, as evidenced by nearly complete absence of implantation sites in e-cigarette-exposed animals at day 5.5, despite exhibiting high levels of progesterone, an indicator of pregnancy. RNA microarray from day 4.5 pseudopregnant mice revealed significant changes in the integrin, chemokine, and JAK signaling pathways. Moreover, female offspring exposed to e-cigarettes
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.