Evidence map›Paper›PMID 31598554›Full record

ArticleScience advances2019

Synthetic networks with tunable responsiveness, biodegradation, and molecular recognition for precision medicine applications.

John R Clegg, Afshan S Irani, Eric W Ander, Catherine M Ludolph, Abhijeet K Venkataraman, Justin X Zhong, Nicholas A Peppas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 89 citations in OpenAlex.

  1. Review
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  5. Designing the Next Generation of Biomaterials through Nanoengineering.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
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  20. Charged Poly(ACS biomaterials science & engineering · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

John R CleggDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-7244-3041
Afshan S IraniDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-5771-0359
Eric W AnderMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Catherine M LudolphMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0001-6912-2311
Abhijeet K VenkataramanDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0001-7279-2789
Justin X ZhongMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Nicholas A PeppasDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0003-0894-5626
The University of Texas at Austin · US

Funding

Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndromeR01EB022025 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI ANSLYN, ERIC V., PEPPAS, NICHOLAS A · 2016 to 2019
$1.5M
NIBIB NIH HHS R01 EB022025
6 · The paper itself

Abstract

Formulations and devices for precision medicine applications must be tunable and multiresponsive to treat heterogeneous patient populations in a calibrated and individual manner. We engineered modular poly(acrylamide-co-methacrylic acid) copolymers, cross-linked into multiresponsive nanogels with either a nondegradable or degradable disulfide cross-linker, that were customized via orthogonal chemistries to target biomarkers of an individual patient's disease or deliver multiple therapeutic modalities. Upon modification with functional small molecules, peptides, or proteins, these nanomaterials delivered methylene blue with environmental responsiveness, transduced visible light for photothermal therapy, acted as a functional enzyme, or promoted uptake by cells. In addition to quantifying the nanogels' composition, physicochemical characteristics, and cytotoxicity, we used a QCM-D method for characterizing nanomaterial degradation and a high-throughput assay for cellular uptake. In conclusion, we generated a tunable nanogel composition for precision medicine applications and new quantitative protocols for assessing the bioactivity of similar platforms.

Indexed as

Drug CarriersPrecision MedicineAcrylic ResinsAnimalsCell Line, TumorHumansMethacrylatesMiceNanogelsNanoparticlesPolyacrylamidesRAW 264.7 CellsAcrylic ResinsDrug CarriersMethacrylatesmethacrylic acidNanogelsPolyacrylamides

Identifiers

PMID31598554
PMCPMC6764836
OpenAlexW2976740715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.