ArticleKorean journal of orthodontics2019
Effects of pre-applied orthodontic force on the regeneration of periodontal tissues in tooth replantation.
Article in Korean journal of orthodontics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Time-course study of genetic changes in periodontal ligament regeneration after tooth replantation in a mouse model.Scientific reports · 2024Article
- Physiological occlusal force attenuates replacement root resorption of replanted teeth: an experimental animal study.BMC oral health · 2024Article
- Periodontal tissue regeneration combined with orthodontic treatment can improve clinical efficacy and periodontal function of patients with periodontitis.American journal of translational research · 2021Article
Corrections and comments
- Commented on byReader's Forum.2020
- Commented on byReader's Forum.2020
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the effect of pre-applied orthodontic force on the regeneration of periodontal ligament (PDL) tissues and the underlying mechanisms in tooth replantation.
methodsOrthodontic force (50 cN) was applied to the left maxillary first molars of 7-week-old male Sprague-Dawley rats (n = 32); the right maxillary first molars were left untreated to serve as the control group. After 7 days, the first molars on both sides were fully luxated and were immediately replanted in their original sockets. To verify the effects of the pre-applied orthodontic force, we assessed gene expression by using microarray analysis and real-time reverse transcription polymerase chain reaction (RT-PCR), cell proliferation by using proliferating cell nuclear antigen (PCNA) immunofluorescence staining, and morphological changes by using histological analysis.
resultsApplication of orthodontic force for 7 days led to the proliferation of PDL tissues, as verified on microarray analysis and PCNA staining. Histological analysis after replantation revealed less root resorption, a better arrangement of PDL fibers, and earlier regeneration of periodontal tissues in the experimental group than in the control group. For the key genes involved in periodontal tissue remodeling, including
conclusionsThese results suggest that the application of orthodontic force prior to tooth replantation enhanced the proliferation and activities of PDL cells and may lead to higher success rates with fewer complications.
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Registered trials
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