Evidence map›Paper›PMID 31598399›Full record

ArticleAmerican journal of cancer research2019

DWI and DCE-MRI approaches for differentiating reversibly electroporated penumbra from irreversibly electroporated ablation zones in a rabbit liver model.

Anna J Shangguan, Chong Sun, Bin Wang, Liang Pan, Quanhong Ma, Su Hu, Jia Yang, Aydin Eresen, Yuri Velichko, Vahid Yaghmai and 1 more

Abstract read
In one paragraph

Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna J ShangguanDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Chong SunDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Bin WangDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Liang PanDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Quanhong MaDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Su HuDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Jia YangDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Aydin EresenDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Yuri VelichkoDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Vahid YaghmaiDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
Zhuoli ZhangDepartment of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.

Funding

MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic CancerR01CA209886 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vahid Yaghmai, Zhuoli Zhang · 2016 to 2026
$3.3M
MRI-Guided Irreversible Electroporation Ablation for Liver TumorsR01CA196967 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZHANG, ZHUOLI · 2015 to 2018
$1.4M
NCI NIH HHS R01 CA196967NCI NIH HHS R01 CA209886
6 · The paper itself

Abstract

The purpose of our study was to investigate the hypothesis that DWI-MRI and DCE-MRI cab be used to distinguish between IRE and RE zones of IRE treatment in a rabbit liver model. 6 rabbits underwent baseline and post-procedure MR imaging with DWI and DCE-MRI as well as IRE (10 pulses, 2000 V, 10 µs/pulse, 10 ms between pulses). Rabbits were euthanized immediately after post-procedure MRI to acquire liver tissue for histology. Liver tissues were fixed and then stained with HE and TUNEL. T1w and T2w intensities in different treatment zones were calculated and normalized to paraspinal muscle signal. ADC maps were generated from DWI. AUC, PE, TTP, WIS, K

Indexed as

DCE-MRIHCCIREMRIperfusion

Identifiers

PMID31598399
PMCPMC6780669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.