Evidence map›Paper›PMID 31598387›Full record

ReviewPrecision clinical medicine2019

Interaction among inflammasome, autophagy and non-coding RNAs: new horizons for drug.

Qinqin Pu, Ping Lin, Zhihan Wang, Pan Gao, Shugang Qin, Luqing Cui, Min Wu

Open access · diamondAbstract readReview
In one paragraph

Review in Precision clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Potential intestinal infection and faecal-oral transmission of SARS-CoV-2.Nature reviews. Gastroenterology & hepatology · 2021
    Review
  4. Crosstalk Between Lung and Extrapulmonary Organs in Infection and Inflammation.Advances in experimental medicine and biology · 2021
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Qinqin PuDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA.
Ping LinDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA.
Zhihan WangWest China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
Pan GaoState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Shugang QinState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Luqing CuiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA.
Min WuDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA.
University of North Dakota · USSichuan University · CNState Key Laboratory of Biotherapy

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
Lung innate immunity against bacterial infectionR01AI109317 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI WU, MIN · 2014 to 2018
$1.7M
Lung epithelium collaborates with alveolar macrophages in host defenseR15AI101973 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI WU, MIN · 2012 to 2012
$414k
Ceramide membrane microdomains regulate cytokine secretionR03AI097532 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI SINGH, BRIJ B · 2012 to 2013
$138k
NIAID NIH HHS R01 AI109317NIAID NIH HHS R03 AI097532NIAID NIH HHS R15 AI101973NIGMS NIH HHS P20 GM103442NIGMS NIH HHS P20 GM113123
6 · The paper itself

Abstract

Autophagy and inflammasomes are shown to interact in various situations including infectious disease, cancer, diabetes and neurodegeneration. Since multiple layers of molecular regulators contribute to the interplay between autophagy and inflammasome activation, the detail of such interplay remains largely unknown. Non-coding RNAs (ncRNAs), which have been implicated in regulating an expanding list of cellular processes including immune defense against pathogens and inflammatory response in cancer and metabolic diseases, may join in the crosstalk between inflammasomes and autophagy in physiological or disease conditions. In this review, we summarize the latest research on the interlink among ncRNAs, inflammasomes and autophagy and discuss the emerging role of these three in multiple signaling transduction pathways involved in clinical conditions. By analyzing these intriguing interconnections, we hope to unveil the mechanism inter-regulating these multiple processes and ultimately discover potential drug targets for some refractory diseases.

Indexed as

autophagyinflammasomeinnate and adaptive immunityncRNAsprecision medicine

Identifiers

PMID31598387
PMCPMC6770284
OpenAlexW2977996592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.