ArticleRoyal Society open science2019
Theoretical study on the toxicity of 'Novichok' agent candidates.
Article in Royal Society open science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Current review on inducible nitric oxide synthase and Src tyrosine kinase inhibitors as disease-modifiers in preclinical models of epilepsy.Histology and histopathology · 2026Review
- VNFlow: integration of variational autoencoders and normalizing flows for novel molecular design.Journal of cheminformatics · 2025Article
- Thiophosphoryl-PMMH Dendrimers for Potential Detection and Remediation of CBRN Contamination: Selected Studies and General Guidelines and Procedures.Materials (Basel, Switzerland) · 2025Article
- Accelerating countermeasure candidate discovery for A-series chemical warfare agent exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Quantum Chemical Mass Spectral Predictions of Novichok Agents after Experimental Validation and Analysis.ACS measurement science au · 2025Article
- History of Organophosphorus Compounds in the Context of Their Use as Chemical Warfare Agents.Molecules (Basel, Switzerland) · 2025Review
- The acute toxicity of Novichok's degradation products using quantitative and qualitative toxicology in silico methods.Archives of toxicology · 2024Article
- A-series agent A-234: initial in vitro and in vivo characterization.Archives of toxicology · 2024Article
- Underestimations in the In Silico-Predicted Toxicities of V-Agents.Journal of xenobiotics · 2023Article
- A-agents, misleadingly known as "Novichoks": a narrative review.Archives of toxicology · 2023Review
- Application of toxicology in silico methods for prediction of acute toxicity (LDArchives of toxicology · 2023Article
- What do we currently know about Novichoks? The state of the art.Archives of toxicology · 2023Review
- Precisely predicting theScientific reports · 2022Article
- Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?Archives of toxicology · 2022Article
- Recent research on Novichok.Archives of toxicology · 2022Article
- FDA-Approved Oximes and Their Significance in Medicinal Chemistry.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Enzymatic Decontamination of G-Type, V-Type and Novichok Nerve Agents.International journal of molecular sciences · 2021Article
- Identification and Study of Biomarkers from Novichok-Inhibited Butyrylcholinesterase in Human Plasma.Molecules (Basel, Switzerland) · 2021Article
- Organophosphorus Nerve Agents: Types, Toxicity, and Treatments.Journal of toxicology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identities and properties of 'Novichok' (Russian for 'newcomer' or 'novice') agents allegedly used in the recent terrorist attack in the UK have not been well documented. Although several people previously involved in the synthesis of these materials claimed Novichok agents to be five to eight times more potent than VX, a deadly nerve agent, no open data on these species are currently available. To bridge this gap, we herein performed a theoretical study on several Novichok agent candidates and conducted natural population charge analysis to evaluate the possible mechanisms of their toxicity, suggesting that these agents might promote the ageing and deformation of acetylcholinesterase. Moreover, the reaction of Novichok agents with acetylcholinesterase serine was calculated to be most thermodynamically favoured for Novichok candidate A234. Thus, this work is believed to provide a basis for finding Novichok antidotes and should inspire further detoxification studies to prepare for possible terrorist attacks in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.