Evidence map›Paper›PMID 31598112›Full record

ArticleContrast media & molecular imaging2019

Radiosynthesis and Preclinical Evaluation of

Assunta Carpinelli, Paolo Rainone, Sara Belloli, Annalisa Reale, Andrea Cappelli, Giuliani Germano, Valentina Murtaj, Angela Coliva, Giuseppe Di Grigoli, Angela Valeri and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Cyclooxygenases as Potential PET Imaging Biomarkers to Explore Neuroinflammation in Dementia.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Assunta Carpinelli *Institute of Molecular Bioimaging and Physiology of CNR, 20090 Segrate, Italy.ORCID 0000-0002-6845-6990
Paolo Rainone *PET and Nuclear Medicine Unit, San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0001-8893-8797
Sara BelloliInstitute of Molecular Bioimaging and Physiology of CNR, 20090 Segrate, Italy.ORCID 0000-0002-3079-3932
Annalisa RealeDepartment of Biotechnology, Chemistry, and Pharmacy, DoE 2018-2022, University of Siena, 53100 Siena, Italy.
Andrea CappelliDepartment of Biotechnology, Chemistry, and Pharmacy, DoE 2018-2022, University of Siena, 53100 Siena, Italy.
Giuliani GermanoDepartment of Biotechnology, Chemistry, and Pharmacy, DoE 2018-2022, University of Siena, 53100 Siena, Italy.
Valentina MurtajInstitute of Molecular Bioimaging and Physiology of CNR, 20090 Segrate, Italy.
Angela ColivaPET and Nuclear Medicine Unit, San Raffaele Scientific Institute, 20132 Milan, Italy.
Giuseppe Di GrigoliInstitute of Molecular Bioimaging and Physiology of CNR, 20090 Segrate, Italy.
Angela ValeriDepartment of Biotechnology, Chemistry, and Pharmacy, DoE 2018-2022, University of Siena, 53100 Siena, Italy.
Maria Carla GilardiInstitute of Molecular Bioimaging and Physiology of CNR, 20090 Segrate, Italy.ORCID 0000-0002-7392-471X
Luigi GianolliPET and Nuclear Medicine Unit, San Raffaele Scientific Institute, 20132 Milan, Italy.
Maurizio AnziniDepartment of Biotechnology, Chemistry, and Pharmacy, DoE 2018-2022, University of Siena, 53100 Siena, Italy.
Rosa Maria MorescoInstitute of Molecular Bioimaging and Physiology of CNR, 20090 Segrate, Italy.
San Raffaele University of Rome · ITUniversity of Siena · ITInstitute of Molecular Bioimaging and Physiology · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclooxygenase-2 (COX-2) is involved in the inflammatory response, and its recurrent overexpression in cancers as well as in neurodegenerative disorders has made it an important target for therapy. For this reason, noninvasive imaging of COX-2 expression may represent an important diagnostic tool. In this work, a COX-2 inhibitor analogue, VA426 [1-(4-fluorophenyl)-3-(2-methoxyethyl)-2-methyl-5-(4-(methylsulfonil)phenyl)-1

Indexed as

Carbon RadioisotopesCyclooxygenase InhibitorsAnimalsBiotransformationCelecoxibCorpus StriatumCyclooxygenase 2Drug Evaluation, PreclinicalDrug StabilityInflammationIsotope LabelingLigandsLipopolysaccharidesLiverMaleMiceCarbon-11Carbon RadioisotopesCelecoxibCyclooxygenase 2Cyclooxygenase InhibitorsLigandsLipopolysaccharidesPtgs2 protein, mousePtgs2 protein, ratRadiopharmaceuticals

Identifiers

PMID31598112
PMCPMC6778861
OpenAlexW2976818169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.