Evidence map›Paper›PMID 31598031›Full record

ArticleJournal Of Elasticity2019

Utilization of the Theory of Small on Large Deformation for Studying Mechanosensitive Cellular Behaviors.

Seungik Baek, Chun Liu, Kun Gou, Jungsil Kim, Hamidreza Gharahi, Christina Chan

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal Of Elasticity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seungik BaekDepartment of Mechanical Engineering, 428 S. Shaw Lane, Michigan State University, East Lansing, MI 48824, US, Tel.: +1-517-432-3161.
Chun LiuDepartment of Chemical Engineering, Michigan State University, East Lansing, MI 48824, US.
Kun GouDepartment of Science and Mathematics, Texas A&M University-San Antonio, San Antonio, TX 78224, US.
Jungsil KimDepartment of Mechanical Engineering and Materials Science, Washington University-St. Louis, MO 63130, US.
Hamidreza GharahiDepartment of Mechanical Engineering, 428 S. Shaw Lane, Michigan State University, East Lansing, MI 48824, US.
Christina ChanDepartment of Chemical Engineering, Michigan State University, East Lansing, MI 48824, US.

Funding

Bioengineered Scaffolds for Spinal Cord InjuryR01EB014986 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAKAMOTO, JEFFREY, TUSZYNSKI, MARK H. · 2012 to 2016
$2.4M
Develop a Dynamic Model that Incoporates Text-mining to Reconstruct NetworksR01GM079688 · NIGMS · MICHIGAN STATE UNIVERSITY · PI CHAN, CHRISTINA · 2007 to 2012
$1.2M
Maximizing siRNA Function through Mechanism-based Sequence and Vehicle DesignR01GM089866 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WALTON, STEPHEN PATRICK · 2010 to 2013
$922k
Growth and Remodeling Model of Abdominal Aortic Aneurysm: Toward Clinical ApplicaR01HL115185 · NHLBI · MICHIGAN STATE UNIVERSITY · PI BAEK, SEUNGIK · 2012 to 2015
$753k
Deep Sequencing to Screen Functional Antibody EpitopesR21CA176854 · NCI · MICHIGAN STATE UNIVERSITY · PI CHAN, CHRISTINA, WHITEHEAD, TIMOTHY ANDREW · 2013 to 2014
$351k
NCI NIH HHS R21 CA176854NHLBI NIH HHS R01 HL115185NIBIB NIH HHS R01 EB014986NIGMS NIH HHS R01 GM079688NIGMS NIH HHS R01 GM089866
6 · The paper itself

Abstract

Recent studies suggest that cells routinely probe their mechanical environments and that this mechanosensitive behavior regulates some of their cellular activities. The finite elasticity theory of small-on-large deformation (SoL) has been shown to be effective in interpreting the mechanosensitive behavior of cells on a substrate that has been subjected to a prior large static stretch before the culturing of the cells. Small on large deformation is the superposition of a small deformation onto a prior large deformation that serves as the new reference configuration. This article aims to refine SoL theory to develop a theoretical framework for improved physical interpretation of mechanosensing. Given the initial large deformation in SoL, the stress generated by the small deformation is linearized, and the linearized elasticity tensor is taken to be a significant factor facilitating prediction of cellular behavior. The pre-stretch is shown to produce direction-based, effective elastic moduli for cellular mechanosensing. The utility of this SoL theory is illustrated by culturing of two different cell types grown on uniaxially pre-stretched surfaces that induce changes to the cell orientation and behavior.

Indexed as

Active sensingMaterial symmetryMyosin II-dependentSmall on largeStatic pre-stretch

Identifiers

PMID31598031
PMCPMC6785204

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.