Evidence map›Paper›PMID 31597963›Full record

ArticleNature2019

Population imaging of neural activity in awake behaving mice.

Kiryl D Piatkevich, Seth Bensussen, Hua-An Tseng, Sanaya N Shroff, Violeta Gisselle Lopez-Huerta, Demian Park, Erica E Jung, Or A Shemesh, Christoph Straub, Howard J Gritton and 6 more

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 257 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Kiryl D Piatkevich *Media Lab, MIT, Cambridge, MA, USA.
Seth Bensussen *Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Hua-An Tseng *Department of Biomedical Engineering, Boston University, Boston, MA, USA.
Sanaya N ShroffDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Violeta Gisselle Lopez-HuertaStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Demian ParkMedia Lab, MIT, Cambridge, MA, USA.
Erica E JungMedia Lab, MIT, Cambridge, MA, USA.
Or A ShemeshMedia Lab, MIT, Cambridge, MA, USA.
Christoph StraubHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Howard J GrittonDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Michael F RomanoDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Emma CostaMedia Lab, MIT, Cambridge, MA, USA.
Bernardo L SabatiniHoward Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Zhanyan FuStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Edward S BoydenMedia Lab, MIT, Cambridge, MA, USA. esb@media.mit.edu.
Xue HanDepartment of Biomedical Engineering, Boston University, Boston, MA, USA. xuehan@bu.edu.
Boston University · USHuman Media · USBroad Institute · USHarvard University · USHoward Hughes Medical Institute · US

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
Novel Platforms for Systematic Optical Control of Complex Neural Circuits In VivoR01DA029639 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2010 to 2023
$6.7M
TRAINING PROGRAM IN QUANTITATIVE BIOLOGY AND PHYSIOLOGYT32GM008764 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI WHITE, JOHN A. · 2001 to 2021
$5.9M
Expansion MicroscopyR01EB024261 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2017 to 2025
$4.6M
Redesigning General Anesthesia (Admin Supp)R01GM104948 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., BROWN, EMERY N · 2012 to 2016
$4.4M
Millisecond-Timescale Whole-Brain Neural Activity Mapping in Health and DiseaseDP1NS087724 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2013 to 2017
$3.9M
Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recordingR01NS109794 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN, HAN, XUE · 2018 to 2022
$3.6M
High-Performance Imaging Through Scattering Living TissueR01DA045549 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2017 to 2020
$3.5M
Light-Actuatable NanoRobots for Molecular UncagingDP2NS082126 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE · 2012 to 2017
$2.9M
RNA Scaffolds for Cell Specific Multiplexed Neural ObservationR01MH114031 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2017 to 2020
$2.8M
Scalable Cell- and Circuit-Targeted ElectrophysiologyR01NS102727 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2017 to 2020
$2.2M
Causal Analysis of Electrically Connected Neural NetworksR01NS087950 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE · 2013 to 2016
$1.3M
NIBIB NIH HHS R01 EB024261NIDA NIH HHS R01 DA029639NIDA NIH HHS R01 DA045549NIGMS NIH HHS R01 GM104948NIGMS NIH HHS T32 GM008764NIMH NIH HHS R01 MH114031NIMH NIH HHS R43 MH109332NIMH NIH HHS T32 MH020016NINDS NIH HHS 1R01NS109794-01NINDS NIH HHS DP1 NS087724NINDS NIH HHS DP2 NS082126NINDS NIH HHS R01 NS081716NINDS NIH HHS R01 NS087950NINDS NIH HHS R01 NS102727NINDS NIH HHS R01 NS109794
6 · The paper itself

Abstract

A longstanding goal in neuroscience has been to image membrane voltage across a population of individual neurons in an awake, behaving mammal. Here we describe a genetically encoded fluorescent voltage indicator, SomArchon, which exhibits millisecond response times and is compatible with optogenetic control, and which increases the sensitivity, signal-to-noise ratio, and number of neurons observable several-fold over previously published fully genetically encoded reagents

Indexed as

Environmental BiomarkersAction PotentialsAnimalsHippocampusMiceNeuronsOptical ImagingOptogeneticsWakefulnessEnvironmental Biomarkers

Identifiers

PMID31597963
PMCPMC6858559
OpenAlexW2979747856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.