ArticleScientific reports2019
Task-evoked Negative BOLD Response and Functional Connectivity in the Default Mode Network are Representative of Two Overlapping but Separate Neurophysiological Processes.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Negative BOLD response to interictal discharges in epilepsy using intracranial EEG-fMRI.Neuroimage. Reports · 2026Article
- Altered functional connectivity underpins cognitive changes in chronic spinal cord injury.Brain communications · 2026Article
- Habenula-ventral tegmental area functional coupling and risk aversion in humans.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phasor diagrams clock oscillatory hemodynamic switching between overt speech production and micro resting states.bioRxiv : the preprint server for biology · 2025Article
- Efficacy Assessment of Cerebral Perfusion Augmentation through Functional Connectivity in an Acute Canine Stroke Model.AJNR. American journal of neuroradiology · 2024Article
- Flow augmentation therapies preserve brain network integrity and hemodynamics in a canine permanent occlusion model.Scientific reports · 2024Article
- Article
- Patterns of retrieval-related cortico-striatal connectivity are stable across the adult lifespan.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Evidence suggesting common mechanisms underlie contralateral and ipsilateral negative BOLD responses in the human visual cortex.NeuroImage · 2022Article
- What has vision science taught us about functional MRI?NeuroImage · 2022Article
- Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Interaction Between Cerebellum and Cerebral Cortex, Evidence from Dynamic Causal Modeling.Cerebellum (London, England) · 2022Article
- Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI.Scientific reports · 2021Article
- Effects of aging on brain networks during swallowing: general linear model and independent component analyses.Scientific reports · 2021Article
- Fully Integrated PET/MR Imaging for the Assessment of the Relationship Between Functional Connectivity and Glucose Metabolic Rate.Frontiers in neuroscience · 2020Article
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2 authors at 1 institution in 1 country.
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Abstract
The topography of the default mode network (DMN) can be obtained with one of two different functional magnetic resonance imaging (fMRI) methods: either from the spontaneous but organized synchrony of the low-frequency fluctuations in resting-state fMRI (rs-fMRI), known as "functional connectivity", or from the consistent and robust deactivations in task-based fMRI (tb-fMRI), here referred to as the "negative BOLD response" (NBR). These two methods are fundamentally different, but their results are often used interchangeably to describe the brain's resting-state, baseline, or intrinsic activity. While the DMN was initially defined by consistent task-based decreases in blood flow in a set of specific brain regions using PET imaging, recently nearly all studies on the DMN employ functional connectivity in rs-fMRI. In this study, we first show the high level of spatial overlap between NBR and functional connectivity of the DMN extracted from the same tb-fMRI scan; then, we demonstrate that the NBR in putative DMN regions can be significantly altered without causing any change in their overlapping functional connectivity. Furthermore, we present evidence that in the DMN, the NBR is more closely related to task performance than the functional connectivity. We conclude that the NBR and functional connectivity of the DMN reflect two separate but overlapping neurophysiological processes, and thus should be differentiated in studies investigating brain-behavior relationships in both healthy and diseased populations. Our findings further raise the possibility that the macro-scale networks of the human brain might internally exhibit a hierarchical functional architecture.
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