Evidence map›Paper›PMID 31597914›Full record

ArticleNature communications2019

Anatomy and function of the vertebral column lymphatic network in mice.

Laurent Jacob, Ligia Simoes Braga Boisserand, Luiz Henrique Medeiros Geraldo, Jose de Brito Neto, Thomas Mathivet, Salli Antila, Besma Barka, Yunling Xu, Jean-Mickael Thomas, Juliette Pestel and 8 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
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  11. VEGF-D-induced intraosseous lymphangiogenesis drives site-specific heterotopic bone resorption.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  20. SPIONActa neuropathologica communications · 2025
    Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 4 countries.

Laurent JacobUniversité Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France.
Ligia Simoes Braga BoisserandDepartment of Neurology, Yale University School of Medicine, New Haven, CT, 06511, USA.
Luiz Henrique Medeiros GeraldoINSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015, Paris, France.
Jose de Brito NetoUniversité Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France.ORCID http://orcid.org/0000-0002-5772-5999
Thomas MathivetINSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015, Paris, France.ORCID http://orcid.org/0000-0001-7761-1684
Salli AntilaWihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Besma BarkaUniversité Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France.
Yunling XuINSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015, Paris, France.
Jean-Mickael ThomasEcole Nationale Supérieure d'Art de la Villa Arson, 06100, Nice, France.
Juliette PestelUniversité Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France.
Marie-Stéphane AigrotUniversité Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France.
Eric SongDepartment of Immunology, Yale University School of Medicine, New Haven, CT, 06510-3221, USA.ORCID http://orcid.org/0000-0001-5448-5865
Harri NurmiWihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Seyoung LeeDepartment of Neurology, Yale University School of Medicine, New Haven, CT, 06511, USA.
Kari AlitaloWihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Nicolas RenierUniversité Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France.ORCID http://orcid.org/0000-0003-2642-4402
Anne EichmannINSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015, Paris, France.
Jean-Leon ThomasUniversité Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, Paris, France. jean-leon.thomas@yale.edu.
Sorbonne Université · FRYale University · USInserm · FRUniversity of Helsinki · FIUniversidade Federal do Rio de Janeiro · BR

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI Jonathan B Demb · 2016 to 2026
$7.1M
Neurovascular RegenerationR01EB016629 · NIBIB · YALE UNIVERSITY · PI HIRSCHI, KAREN KEMPER · 2014 to 2018
$4.8M
Targeting endothelial migration to prevent neovascularizationR01HL125811 · NHLBI · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE · 2015 to 2025
$4.1M
Novel approaches to manipulate sprouting angiogenesisR01EY025979 · NEI · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE · 2015 to 2019
$1.9M
Novel approached to prevent diet-induced obesity via lacteal junctionsR01DK120373 · NIDDK · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE · 2019 to 2022
$1.5M
Meningeal lymphangiogenesis effect on malignancy ofglioblastoma.F30CA239444 · NCI · YALE UNIVERSITY · PI SONG, HOYEON ERIC · 2019 to 2021
$111k
NCI NIH HHS F30 CA239444NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY025979NHLBI NIH HHS R01 HL125811NIBIB NIH HHS R01 EB016629NIDDK NIH HHS R01 DK120373NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Cranial lymphatic vessels (LVs) are involved in the transport of fluids, macromolecules and central nervous system (CNS) immune responses. Little information about spinal LVs is available, because these delicate structures are embedded within vertebral tissues and difficult to visualize using traditional histology. Here we show an extended vertebral column LV network using three-dimensional imaging of decalcified iDISCO

Indexed as

AnimalsImage Processing, Computer-AssistedLymphatic VesselsLymph NodesMaleMice, Inbred C57BLMice, TransgenicMicroscopy, ConfocalMicroscopy, FluorescenceSpinal Cord InjuriesSpineThoracic Duct

Identifiers

PMID31597914
PMCPMC6785564
OpenAlexW2979612914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.