Evidence map›Paper›PMID 31597766›Full record

ArticleJournal of virology2019

Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression

Vikas Peddu, Isabelle Dubuc, Annie Gravel, Hong Xie, Meei-Li Huang, Dan Tenenbaum, Keith R Jerome, Jean-Claude Tardif, Marie-Pierre Dubé, Louis Flamand and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Alveolar macrophage-neutrophil crosstalk in acute lung injury: mechanisms, feedback loops, and therapeutic opportunities.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  4. Article
  5. Article
  6. Endogenous human herpesviruses 6A/B.Journal of virology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Vikas Peddu *Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Isabelle Dubuc *CHU de Quebec Research Center-Université Laval, Quebec City, Québec, Canada.
Annie GravelCHU de Quebec Research Center-Université Laval, Quebec City, Québec, Canada.
Hong XieDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Meei-Li HuangDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Dan TenenbaumFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Keith R JeromeDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Jean-Claude TardifMontreal Heart Institute, Montréal, Québec, Canada.
Marie-Pierre DubéMontreal Heart Institute, Montréal, Québec, Canada.
Louis FlamandCHU de Quebec Research Center-Université Laval, Quebec City, Québec, Canada louis.flamand@crchudequebec.ulaval.ca agrening@uw.edu.
Alexander L GreningerDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA louis.flamand@crchudequebec.ulaval.ca agrening@uw.edu.
University of Washington · USUniversité Laval · CAFred Hutch Cancer Center · USMontreal Heart Institute · CAUniversité de Montréal · CA

Funding

CIHR
6 · The paper itself

Abstract

Human herpesviruses 6A and 6B (HHV-6A and HHV-6B) are human viruses capable of chromosomal integration. Approximately 1% of the human population carries one copy of HHV-6A/B integrated into every cell in their body, referred to as inherited chromosomally integrated human herpesvirus 6A/B (iciHHV-6A/B). Whether iciHHV-6A/B is transcriptionally active

Indexed as

Adrenal GlandsAgedAntibodies, ViralBrainChromosomes, HumanCohort StudiesCytomegalovirusEsophagusFemaleHerpesvirus 4, HumanHerpesvirus 6, HumanHumansInheritance PatternsMaleMiddle AgedOrgan SpecificityAntibodies, ViralRNA, Viralantibody responseciHHV-6Genotype Tissue Expression projectGTExHHV-6Human herpesvirus 6iciHHV-6IE1LIPSU90

Identifiers

PMID31597766
PMCPMC6912112
OpenAlexW2979639930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.