Evidence map›Paper›PMID 31597762›Full record

ArticleJournal of virology2019

Mouse Cytomegalovirus m153 Protein Stabilizes Expression of the Inhibitory NKR-P1B Ligand Clr-b.

Oscar A Aguilar, Isabella S Sampaio, Mir Munir A Rahim, Jackeline D Samaniego, Mulualem E Tilahun, Mithunah Krishnamoorthy, Branka Popović, Marina Babić, Astrid Krmpotić, Bebhinn Treanor and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Oncolytic α-herpesvirus and myeloid-tropic cytomegalovirus cooperatively enhance systemic antitumor responses.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Oscar A AguilarDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada oscar.aguilar@ucsf.edu james.carlyle@utoronto.ca.
Isabella S SampaioDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Mir Munir A RahimDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Jackeline D SamaniegoDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Mulualem E TilahunLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Mithunah KrishnamoorthyDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Branka PopovićDepartment for Histology and Embryology, University of Rijeka, Rijeka, Croatia.
Marina BabićDepartment for Histology and Embryology, University of Rijeka, Rijeka, Croatia.
Astrid KrmpotićDepartment for Histology and Embryology, University of Rijeka, Rijeka, Croatia.
Bebhinn TreanorDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
David H MarguliesLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
David S J AllanDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
Andrew P MakrigiannisDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Stipan JonjićDepartment for Histology and Embryology, University of Rijeka, Rijeka, Croatia.
James R CarlyleDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada oscar.aguilar@ucsf.edu james.carlyle@utoronto.ca.
University of Toronto · CAUniversity of Rijeka · HRNational Institute of Allergy and Infectious Diseases · USUniversity of Ottawa · CA

Funding

Structure and Function of Viral ImmunoevasinsZIAAI001028 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MARGULIES, DAVID · 2009 to 2025
$7.9M
CIHR 106491CIHR 136808CIHR 86630Intramural NIH HHS ZIA AI001028
6 · The paper itself

Abstract

Natural killer (NK) cells are a subset of innate lymphoid cells (ILC) capable of recognizing stressed and infected cells through multiple germ line-encoded receptor-ligand interactions. Missing-self recognition involves NK cell sensing of the loss of host-encoded inhibitory ligands on target cells, including MHC class I (MHC-I) molecules and other MHC-I-independent ligands. Mouse cytomegalovirus (MCMV) infection promotes a rapid host-mediated loss of the inhibitory NKR-P1B ligand Clr-b (encoded by

Indexed as

AnimalsGene Expression RegulationGenetic Complementation TestHerpesviridae InfectionsHost-Pathogen InteractionsImmunity, InnateKiller Cells, NaturalLectins, C-TypeMiceMice, Inbred C57BLMice, KnockoutMuromegalovirusNIH 3T3 CellsNK Cell Lectin-Like Receptor Subfamily BReceptors, ImmunologicSignal TransductionClec2d protein, mouseKlrb1b protein, mouseLectins, C-TypeNK Cell Lectin-Like Receptor Subfamily BReceptors, ImmunologicViral Matrix Proteinshost-pathogen interactionsm145 familyMCMVmissing-self recognitionmouse cytomegalovirusnatural killer cellnatural killer cellsNkrp1-Clrviral immune evasion

Identifiers

PMID31597762
PMCPMC6912091
OpenAlexW2979621346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.