Evidence map›Paper›PMID 31597750›Full record

ArticleJournal of clinical microbiology2019

A Multiplexed Serologic Test for Diagnosis of Lyme Disease for Point-of-Care Use.

Siddarth Arumugam, Samiksha Nayak, Taylor Williams, Francesco Serra di Santa Maria, Mariana Soares Guedes, Rodrigo Cotrim Chaves, Vincent Linder, Adriana R Marques, Elizabeth J Horn, Susan J Wong and 2 more

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Understanding the Perspectives, Experiences, Beliefs, and Knowledge of Health Care Practitioners on the Diagnosis and Treatment of Lyme Disease in Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025
    Article
  7. Article
  8. Review
  9. Cholesterol Contributes to Risk, Severity, and Machine Learning-Driven Diagnosis of Lyme Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  10. Review
  11. Electrochemical Detection ofACS measurement science au · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Serologic Response toJournal of clinical microbiology · 2021
    Article
  18. Identification of Immunogenic Linear B-Cell Epitopes inPathogens (Basel, Switzerland) · 2021
    Article
  19. Discovery and Surveillance of Tick-Borne Pathogens.Journal of medical entomology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Siddarth Arumugam *Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Samiksha Nayak *Department of Biomedical Engineering, Columbia University, New York, New York, USA.
Taylor WilliamsImmuno Technologies Inc., Memphis, Tennessee, USA.
Francesco Serra di Santa MariaDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Mariana Soares GuedesImmuno Technologies Inc., Memphis, Tennessee, USA.
Rodrigo Cotrim ChavesDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Vincent LinderOpko Diagnostics LLC, Woburn, Massachusetts, USA.
Adriana R MarquesLyme Disease Studies Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-5403-4551
Elizabeth J HornLyme Disease Biobank, Portland, Oregon, USA.
Susan J WongWadsworth Center, New York State Department of Health, Axelrod Institute, Albany, New York, USA.
Samuel K SiaDepartment of Biomedical Engineering, Columbia University, New York, New York, USA ss2735@columbia.edu mgomesso@uthsc.edu.
Maria Gomes-SoleckiImmuno Technologies Inc., Memphis, Tennessee, USA ss2735@columbia.edu mgomesso@uthsc.edu.ORCID 0000-0002-3715-4543
Columbia University · USUniversity of Tennessee Health Science Center · USImmuno Technologies (United States) · USNational Institutes of Health · USNew York State Department of Health · US

Funding

Field trial and modeling of transmission blocking vaccine to prevent Lyme diseaseR01AI139267 · NIAID · UNIVERSITY OF IOWA · PI BROWN, GRANT D, GOMES-SOLECKI, MARIA · 2019 to 2023
$3.6M
Lab on a chip point of care assay for the rapid serodiagnosis of Lyme diseaseR44AI096551 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2014 to 2016
$3.0M
Point of care assay for serodiagnosis of LeptospirosisR43AI136551 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2018 to 2019
$600k
Role of TLR4 in persistent Leptospira infectionR21AI142129 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GOMES-SOLECKI, MARIA · 2019 to 2020
$418k
NIAID NIH HHS R01 AI139267NIAID NIH HHS R21 AI142129NIAID NIH HHS R43 AI136551NIAID NIH HHS R44 AI096551
6 · The paper itself

Abstract

Single multiplexed assays could replace the standard 2-tiered (STT) algorithm recommended for the laboratory diagnosis of Lyme disease if they perform with a specificity and a sensitivity superior or equal to those of the STT algorithm. We used human serum rigorously characterized to be sera from patients with acute- and convalescent-phase early Lyme disease, Lyme arthritis, and posttreatment Lyme disease syndrome, as well as the necessary controls (

Indexed as

Point-of-Care SystemsBorrelia burgdorferiHumansLyme DiseaseMicrofluidicsSensitivity and SpecificitySerologic TestsBorrelia burgdorferiearly Lymelate LymeLyme diseasemChip-Ldmicrofluidicspoint of careserodiagnosticserology

Identifiers

PMID31597750
PMCPMC6879297
OpenAlexW2979399726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.