Evidence map›Paper›PMID 31597746›Full record

ArticleJournal of clinical microbiology2019

Noninvasive Detection of Antibodies to Human T-Cell Lymphotropic Virus Types 1 and 2 by Use of Oral Fluid.

Timothy Woo, Carolina Rosadas, Samreen Ijaz, Steve Dicks, Jennifer H C Tosswill, Richard S Tedder, Graham P Taylor

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Timothy Woo *Department of Infectious Disease, Imperial College London, London, United Kingdom.
Carolina Rosadas *Department of Infectious Disease, Imperial College London, London, United Kingdom.
Samreen IjazBlood Borne Virus Unit, Virus Reference Department, Public Health England, London, United Kingdom.
Steve DicksBlood Borne Virus Unit, Virus Reference Department, Public Health England, London, United Kingdom.
Jennifer H C TosswillBlood Borne Virus Unit, Virus Reference Department, Public Health England, London, United Kingdom.
Richard S TedderDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Graham P TaylorDepartment of Infectious Disease, Imperial College London, London, United Kingdom g.p.taylor@imperial.ac.uk.
Imperial College London · GBPublic Health England · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human T-lymphotropic viruses type 1 and 2 (HTLV-1/2) are prevalent in endemic clusters globally, and HTLV-1 infects at least 5 to 10 million individuals. Infection can lead to inflammation in the spinal cord, resulting in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), or adult T cell leukemia/lymphoma (ATL). Obtaining venous blood for serological screening, typically performed using enzyme immunoassays (EIAs), is invasive, sometimes socially unacceptable, and has restricted large-scale seroprevalence studies. Collecting oral fluid (OF) is a noninvasive alternative to venesection. In this study, an IgG antibody capture EIA was developed and validated to detect anti-HTLV-1/2 IgG in OF. OF and plasma specimens were obtained from seropositive HTLV-1/2-infected patients attending the National Centre for Human Retrovirology (

Indexed as

AdultAgedAged, 80 and overAnimalsAntibodies, ViralFemaleHTLV-II InfectionsHTLV-I InfectionsHumansImmunoassayImmunoglobulin GMaleMiddle AgedReproducibility of ResultsSalivaSensitivity and SpecificityAntibodies, ViralImmunoglobulin GdiagnosticsELISAgingival crevicular fluidHTLV-1HTLV-2human T-cell leukemia virusIgGimmunoassaysimmunodiagnosticsoral fluid

Identifiers

PMID31597746
PMCPMC6879298
OpenAlexW2990268328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.