Evidence map›Paper›PMID 31597737›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

GIGANTEA gates gibberellin signaling through stabilization of the DELLA proteins in

Maria A Nohales, Steve A Kay

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. GIGANTEA adjusts the response to shade at dusk by directly impinging on PHYTOCHROME INTERACTING FACTOR 7 function.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Genes · 2024
    Review
  13. The Roles of Circadian Clock Genes in Plant Temperature Stress Responses.International journal of molecular sciences · 2024
    Review
  14. Investigating Circadian Gating of Temperature Responsive Genes.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  15. Article
  16. Current Insights into mPlants (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria A NohalesKeck School of Medicine, University of Southern California, Los Angeles, CA 90089 nohalesz@usc.edu stevekay@usc.edu.
Steve A KayKeck School of Medicine, University of Southern California, Los Angeles, CA 90089 nohalesz@usc.edu stevekay@usc.edu.ORCID 0000-0002-0402-2878
University of Southern California · US

Funding

GENETIC ANALYSIS OF CIRCADIAN RHYTHMS IN ARABIDOPSISR01GM056006 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAY, STEVE A, PRUNEDA-PAZ, JOSE L · 1996 to 2016
$6.0M
Molecular Mechanisms in the Arabidopsis Circadian ClockR01GM067837 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAY, STEVE A · 2003 to 2015
$4.7M
Molecular Mechanisms in the Arabidopsis Circadian ClockR37GM067837 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI STEVE A KAY · 2017 to 2026
$4.4M
NIGMS NIH HHS R01 GM056006NIGMS NIH HHS R01 GM067837NIGMS NIH HHS R37 GM067837
6 · The paper itself

Abstract

Circadian clock circuitry intersects with a plethora of signaling pathways to adequately time physiological processes to occur at the most appropriate time of the day and year. However, our mechanistic understanding of how the clockwork is wired to its output is limited. Here we uncover mechanistic connections between the core clock component GIGANTEA (GI) and hormone signaling through the modulation of key components of the transduction pathways. Specifically, we show how GI modulates gibberellin (GA) signaling through the stabilization of the DELLA proteins, which act as negative components in the signaling of this hormone. GI function within the GA pathway is required to precisely time the permissive gating of GA sensitivity, thereby determining the phase of GA-regulated physiological outputs.

Indexed as

ArabidopsisArabidopsis ProteinsCircadian ClocksGibberellinsSignal TransductionArabidopsis ProteinsGAI protein, ArabidopsisGibberellinsGI protein, Arabidopsiscircadian clockgatinggibberellin signalingGIGANTEAoutput oscillations

Identifiers

PMID31597737
PMCPMC6815129
OpenAlexW2980271905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.