Evidence map›Paper›PMID 31597706›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8

Cybelle Tabilas, Jocelyn Wang, Xiaojing Liu, Jason W Locasale, Norah L Smith, Brian D Rudd

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Early-life human CD8Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Regulation of HSC development and function by Lin28b.Frontiers in cell and developmental biology · 2025
    Review
  8. Review
  9. Neonatal CD8+ T Cells Resist Exhaustion during Chronic Infection.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Neonatal T Cells: A Reinterpretation.Annual review of immunology · 2020
    Review
  19. Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cybelle TabilasDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-5846-7269
Jocelyn WangDepartment of Pediatrics, Indiana University, Indianapolis, IN 46202.ORCID 0000-0003-0016-3136
Xiaojing LiuDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695; and.ORCID 0000-0002-4231-6017
Jason W LocasaleDepartment of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710.ORCID 0000-0002-7766-3502
Norah L SmithDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853.
Brian D RuddDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853; bdr54@cornell.edu.

Funding

The developmental layers in the CD8+ T cell response to chronic infectionR01AI110613 · NIAID · CORNELL UNIVERSITY · PI GRIMSON, ANDREW W, RUDD, BRIAN DAVID · 2014 to 2022
$4.1M
Mechanisms Limiting Neonatal ImmunityR01AI105265 · NIAID · CORNELL UNIVERSITY · PI RUDD, BRIAN DAVID · 2014 to 2023
$4.0M
Immuno-Engineering: Integrated Engineering and Immunology TrainingT32EB023860 · NIBIB · CORNELL UNIVERSITY · PI AUGUST, AVERY, PUTNAM, DAVID A · 2018 to 2022
$933k
NIAID NIH HHS R01 AI105265NIAID NIH HHS R01 AI110613NIBIB NIH HHS T32 EB023860
6 · The paper itself

Abstract

Neonates often develop poor immunity against intracellular pathogens. Because CD8

Indexed as

Adoptive TransferAnimalsAnimals, NewbornCD8-Positive T-LymphocytesCells, CulturedDeoxyglucoseGlycolysisImmunologic MemoryInterleukin-2Listeria monocytogenesListeriosisMiceMice, Inbred C57BLMice, TransgenicRNA-Binding ProteinsDeoxyglucoseInterleukin-2Lin28b protein, mouseRNA-Binding Proteins

Identifiers

PMID31597706
PMCPMC6832862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.