Evidence map›Paper›PMID 31597698›Full record

ArticleThe Journal of biological chemistry2019

β-Catenin mutations as determinants of hepatoblastoma phenotypes in mice.

Weiqi Zhang, Jennifer Meyfeldt, Huabo Wang, Sucheta Kulkarni, Jie Lu, Jordan A Mandel, Brady Marburger, Ying Liu, Joanna E Gorka, Sarangarajan Ranganathan and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis.The American journal of pathology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Lessons in aging from Myc knockout mouse models.Frontiers in cell and developmental biology · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Surgical Pathology Diagnostic Pitfalls of Hepatoblastoma.International journal of surgical pathology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Weiqi ZhangDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Jennifer MeyfeldtDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Huabo WangDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.ORCID 0000-0003-2551-3243
Sucheta KulkarniDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Jie LuDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Jordan A MandelDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Brady MarburgerDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Ying LiuDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Joanna E GorkaDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Sarangarajan RanganathanUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Edward V ProchownikDivision of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15224 procev@chp.edu.ORCID 0000-0001-9666-8205
Children's Hospital of Pittsburgh · USUniversity of Pittsburgh · US

Funding

Control of Metabolism and Energy-Sensing Pathways by c-MycR01CA174713 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PROCHOWNIK, EDWARD VICTOR · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA174713
6 · The paper itself

Abstract

Hepatoblastoma (HB) is the most common pediatric liver cancer. Although long-term survival of HB is generally favorable, it depends on clinical stage, tumor histology, and a variety of biochemical and molecular features. HB appears almost exclusively before the age of 3 years, is represented by seven histological subtypes, and is usually associated with highly heterogeneous somatic mutations in the catenin β1 (

Indexed as

Animalsbeta CateninCell ProliferationHepatoblastomaLiver NeoplasmsMiceMutationTranscriptional ActivationTranscriptomebeta CateninCTNNB1 protein, mousebeta-catenin (B-catenin)catenin beta1 (CTNNB1)glutaminolysisglycolysishepatoblastoma (HB)MYC proto-oncogene BHLH transcription factor (c-Myc)oxidative phosphorylationpediatric cancerpyruvate dehydrogenase complex (PDC)Warburg effectWnt pathwayyes-associated protein (YAP)

Identifiers

PMID31597698
PMCPMC6873193
OpenAlexW2980227099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.