Evidence map›Paper›PMID 31597601›Full record

ReviewTrends in cognitive sciences2019

Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity.

Shauna M Stark, C Brock Kirwan, Craig E L Stark

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 170 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05846425 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Investigating the Effect of Yoga-based Breathing Styles on the Human Brain, With a Focus on Memory

TypeinterventionalSponsorUniversität des SaarlandesRan2023 to 2024Enrolled75ConditionsHypoventilation, HyperventilationArmsNose-breathing training, Mouth-breathing training
NCT06588946 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Exogenous Β-OHB Supplementation on Cerebral Blood Flow and Functional Brain Characteristics in Adults with Subjective Cognitive Decline

TypeinterventionalSponsorMcMaster UniversityRan2025 to 2027Enrolled48ConditionsSubjective Cognitive DeclineArmsKetone monoester (KME) supplement, Placebo supplement
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  14. The human hippocampus can pattern separate memories by meaning.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  17. Demographically adjusted norms for a French-Quebec version of the face-name associative recognition test.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026
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110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shauna M StarkDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA.
C Brock KirwanDepartment of Psychology, Neuroscience Center, Brigham Young University, Provo, UT, USA.
Craig E L StarkDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA. Electronic address: cestark@uci.edu.

Funding

High-resolution Structural and Functional Brain Imaging of the Medial Temporal LoR01AG034613 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI STARK, CRAIG E · 2009 to 2018
$4.6M
NIA NIH HHS R01 AG034613
6 · The paper itself

Abstract

The hippocampus is critical for learning and memory, relying in part on pattern separation processes supported by the dentate gyrus (DG) to prevent interference from overlapping memory representations. In 2007, we designed the Mnemonic Similarity Task (MST), a modified object recognition memory task, to be highly sensitive to hippocampal function by placing strong demands on pattern separation. The MST is now a widely used behavioral task, repeatedly shown to be sensitive to age-related memory decline, hippocampal connectivity, and hippocampal function, with specificity to the DG. Here, we review the utility of the MST, its relationship to hippocampal function, its utility in detecting hippocampal-based memory alterations across the lifespan, and impairments associated with clinical pathology from a variety of disorders.

Indexed as

Memory and Learning TestsHippocampusHumansMemory DisordersPattern Recognition, VisualRecognition, Psychologydiscriminationhippocampusmnemonic similaritypattern separation

Identifiers

PMID31597601
PMCPMC6991464

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.