ArticleAntioxidants (Basel, Switzerland)2019
Enhanced Recovery of Antioxidant Compounds from Hazelnut (
Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
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- Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos.Molecules (Basel, Switzerland) · 2023Article
- The Effect of Extraction Methods on Phytochemicals and Biological Activities of Green Coffee Beans Extracts.Plants (Basel, Switzerland) · 2023Article
- Study of the Apoptotic Impacts of Hazelnut Oil on the Colorectal Cancer Cell Line.Advanced biomedical research · 2023Article
- UPLC-MS/MS profiling, antioxidant and anti-inflammatory activities, and potential health benefits prediction of phenolic compounds in hazel leaf.Frontiers in nutrition · 2023Article
- Article
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- Evaluation of theFrontiers in chemistry · 2022Article
- Probiotic fermentation improves the bioactivities and bioaccessibility of polyphenols inFrontiers in nutrition · 2022Article
- A comparative study of nutrient composition, bioactive properties and phytochemical characteristics ofFrontiers in nutrition · 2022Article
- Hazelnut Shells as Source of Active Ingredients: Extracts Preparation and Characterization.Molecules (Basel, Switzerland) · 2021Article
- Enhanced Recovery of Phenolic and Tocopherolic Compounds from Walnut (Antioxidants (Basel, Switzerland) · 2021Article
- Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut (Antioxidants (Basel, Switzerland) · 2021Article
- Optimization of a Green Ultrasound-Assisted Extraction of Different Polyphenols fromPlants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tree nut by-products could contain a wide range of phytochemicals, natural antioxidants, which might be used as a natural source for dietary supplements. The aim of the present study was to evaluate the phenolic and sterolic composition, as well as the antioxidant and other biological activities, of hazelnut involucre (HI) extracts. Experimental designs were developed in order to select the optimum extraction conditions (solvent, temperature, time) using turbo-extraction by Ultra-Turrax for obtaining extracts rich in bioactive compounds. Qualitative and quantitative analyses were performed by LC-MS and LC-MS/MS and they revealed important amounts of individual polyphenols and phytosterols, molecules with antioxidant potential. The richest polyphenolic HI extract with the highest antioxidant activity by TEAC assay was further evaluated by other in vitro antioxidant tests (DPPH, FRAP) and enzyme inhibitory assays. Additionally, the cytotoxic and antioxidant effects of this extract on two cancerous cell lines and on normal cells were tested. This is the first study to analyze the composition of both hydrophilic and lipophilic bioactive compounds in HI extracts. Our findings reveal that this plant by-product presents strong biological activities, justifying further research, and it could be considered an inexpensive source of natural antioxidants for food, pharmaceutical, or cosmetic industry.
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Registered trials
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