Evidence map›Paper›PMID 31597360›Full record

SynthesisNutrients2019

The Effect of the Yingyangbao Complementary Food Supplement on the Nutritional Status of Infants and Children: A Systematic Review and Meta-Analysis.

Zhihui Li, Xinyi Li, Christopher R Sudfeld, Yuning Liu, Kun Tang, Yangmu Huang, Wafaie Fawzi

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06827964 (Effects of Nutrition Package), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06827964 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Nutrition Package (Yingyangbao) Intervention on Children and Adolescents' Health in Myanmar

TypeinterventionalSponsorTsinghua UniversityRan2025 to 2025Enrolled600ConditionsMalnutrition in ChildrenArmsSoy-based Nutrition Package, Probiotics
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  4. Observational
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  8. Approaches to Address the Anemia Challenge.The Journal of nutrition · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Zhihui LiDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. zhl922@mail.harvard.edu.
Xinyi LiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. xinyili@hsph.harvard.edu.
Christopher R SudfeldDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. crsudfeld@gmail.com.
Yuning LiuDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. lynpkuhsc@126.com.
Kun TangResearch Center for Public Health, School of Medicine, Tsinghua University, Beijing 100084, China. tangk@mail.tsinghua.edu.cn.
Yangmu HuangDepartment of Global Health, School of Public Health, Peking University, Beijing 100191, China. ymhuang@bjmu.edu.cn.
Wafaie FawziDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. mina@hsph.harvard.edu.
Harvard University · USHarvard Global Health Institute · USPeking University · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yingyangbao (YYB) is a nutrient-dense complementary food supplement for infants and young children in China. There has been considerable interest and research on the potential effects of YYB on hematological and anthropometric outcomes in China, but limited effort has been made to consolidate and synthesize the evidence to inform the research and policy agendas. Eight English databases and three Chinese databases were searched from January 2001 to June 2019 to identify YYB intervention studies. A total of 32 quasi-experimental, post-only, concurrent-control studies or pre-post studies were identified, and 26 were included in the meta-analyses. A pooled analysis of post-only studies with concurrent-control determined that YYB was associated with an increase of 4.43 g/L (95% confidence interval (CI) 1.55, 7.30) hemoglobin concentration, 2.46 cm (CI 0.96, 3.97) in height, and 0.79 kg (CI 0.25, 1.32) weight in infants and young children. YYB was also associated with reductions in the prevalence of anemia (risk ratio (RR) = 0.55; 95% CI: 0.45, 0.67), stunting (RR = 0.60; 95% CI: 0.44, 0.81), and underweight (RR = 0.51; 95% CI: 0.39, 0.65). Overall, YYB was found to be associated with improved hematological and anthropometric indicators among infants and young children in China; however, randomized trials are needed to causally assess the efficacy of YYB due to the inherent risk of bias in existing quasi-experimental studies; rigorous implementation and cost-effectiveness evaluations are also needed.

Indexed as

Infant Nutritional Physiological PhenomenaNutritional StatusAnemiaBody HeightChild, PreschoolChinaDietary SupplementsGlycine maxGrowth DisordersHemoglobinsHumansInfantInfant FoodMEDLINEMicronutrientsPovertyHemoglobinsMicronutrientsanthropometric statusfood supplementhematological statusinfant and childrenYingyangbao

Identifiers

PMID31597360
PMCPMC6835467
OpenAlexW2980087983

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.