ReviewNutrients2019
Dietary Protein, Exercise, and Frailty Domains.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Trial
- Healthcare and non-healthcare professionals' knowledge about nutrition in older adults: a cross-sectional study.BMC public health · 2025Article
- Effects of Protein Intake on Cognitive Function in Chinese Older Adults: A 10-Year Follow-Up Study.Nutrients · 2025Article
- Association of cooking oil and incident of frailty in older adults: a cohort study.BMC geriatrics · 2024Article
- Article
- Prehabilitation for frail patients undergoing total hip or knee replacement: protocol for the Joint PREP feasibility randomised controlled trial.Pilot and feasibility studies · 2023Article
- Dairy Food Intake Is Not Associated With Frailty in Adults From the Framingham Heart Study.Journal of the Academy of Nutrition and Dietetics · 2023Article
- Frailty at Risk Scale (FARS): development and application.European journal of ageing · 2022Article
- Protein Nutritional Status and Frailty: A Mendelian Randomization Study.The Journal of nutrition · 2022Article
- Associations between lifestyle factors and multidimensional frailty: a cross-sectional study among community-dwelling older people.BMC geriatrics · 2022Article
- Isolated Soy Protein Supplementation Combined With Resistance Training Improves Muscle Strength, Mass, and Physical Performance of Aging Female Mice.Frontiers in physiology · 2022Article
- Association of regular aerobic exercises and neuromuscular junction variants with incidence of frailty: an analysis of the Chinese Longitudinal Health and Longevity Survey.Journal of cachexia, sarcopenia and muscle · 2021Article
- Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management.Frontiers in nutrition · 2021Review
- Lessons Learned in Nutrition Therapy in Patients With Severe COVID-19.JPEN. Journal of parenteral and enteral nutrition · 2020Article
- Macronutrient intake and frailty: the Rotterdam Study.European journal of nutrition · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing awareness of the impact of frailty on elderly people resulted in research focusing on factors that contribute to the development and persistence of frailty including nutrition and physical activity. Most effort so far has been spent on understanding the association between protein intake and the physical domain of frailty. Far less is known for other domains of frailty: cognition, mood, social health and comorbidity. Therefore, in the present narrative review, we elaborate on the evidence currently known on the association between protein and exercise as well as the broader concept of frailty. Most, but not all, identified studies concluded that low protein intake is associated with a higher prevalence and incidence of physical frailty. Far less is known on the broader concept of frailty. The few studies that do look into this association find a clear beneficial effect of physical activity but no conclusions regarding protein intake can be made yet. Similar, for other important aspects of frailty including mood, cognition, and comorbidity, the number of studies are limited and results are inconclusive. Future studies need to focus on the relation between dietary protein and the broader concept of frailty and should also consider the protein source, amount and timing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.