ReviewInternational journal of molecular sciences2019
Protective Effects of Melatonin on the Skin: Future Perspectives.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Skin Aging and Carotenoids: A Systematic Review of Their Multifaceted Protective Mechanisms.Nutrients · 2025Pooled it
- Microbiome-Directed Bioactive Strategies in Skin Aging: Mechanistic Insights and Precision Nanocarrier Delivery Approaches.Molecules (Basel, Switzerland) · 2026Review
- Enhancing melatonin biosynthesis in crops through synthetic genetic circuits: A strategy for nutritional fortification in soybean and stress resistance in cotton.Plant biotechnology journal · 2025Article
- Melatonin and the Skin: Current Progress and Perspectives for Human Health.The Journal of investigative dermatology · 2025Review
- Fabrication of 3D Printed Microneedle Patch for the Simultaneous Delivery and Detection of Melatonin from Interstitial Fluid.AAPS PharmSciTech · 2025Article
- Recent advances in the mechanisms, current treatment status, and application of multifunctional biomaterials for radiation-induced skin injury.Theranostics · 2025Review
- Preparing the soil: Adjusting the metabolic health of patients with chronic wounds and musculoskeletal diseases.International wound journal · 2024Review
- Keratinocyte derived extracellular vesicles mediated crosstalk between epidermis and dermis in UVB-induced skin inflammation.Cell communication and signaling : CCS · 2024Article
- Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice.Journal of pharmaceutical analysis · 2024Article
- Biosynthesis of melatonin from L-tryptophan by an engineered microbial cell factory.Biotechnology for biofuels and bioproducts · 2024Article
- Melatonin in animal husbandry: functions and applications.Frontiers in veterinary science · 2024Review
- Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing.Mini reviews in medicinal chemistry · 2024Review
- Intestinal melatonin levels and gut microbiota homeostasis are independent of the pineal gland in pigs.Frontiers in microbiology · 2024Article
- Causal associations between modifiable risk factors and isolated REM sleep behavior disorder: a mendelian randomization study.Frontiers in neurology · 2024Article
- [Melatonin reverses oxidative damage in the submandibular gland of rats treated with Cyclophosphamide].Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2023Article
- Controlled release of bilayer tablet comprising vitamin BPharmaceutical science advances · 2023Article
- Natural Retinol Analogs Potentiate the Effects of Retinal on Aged and Photodamaged Skin: Results from In Vitro to Clinical Studies.Dermatology and therapy · 2023Article
- Influence of Various Light Regimes on Morphofunctional Condition of Transplantable Melanoma B16.Biomedicines · 2023Article
- Chitosan-sEPDM and Melatonin-Chitosan-sEPDM Composite Membranes for Melatonin Transport and Release.Membranes · 2023Article
- Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When exposed to hostile environments such as radiation, physical injuries, chemicals, pollution, and microorganisms, the skin requires protective chemical molecules and pathways. Melatonin, a highly conserved ancient molecule, plays a crucial role in the maintenance of skin. As human skin has functional melatonin receptors and also acts as a complete system that is capable of producing and regulating melatonin synthesis, melatonin is a promising candidate for its maintenance and protection. Below, we review the studies of new metabolic pathways involved in the protective functions of melatonin in dermal cells. We also discuss the advantages of the topical use of melatonin for therapeutic purposes and skin protection. In our view, endogenous intracutaneous melatonin production, together with topically-applied exogenous melatonin and its metabolites, represent two of the most potent defense systems against external damage to the skin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.