ArticleNature2019
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.
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In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,129 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,129citing papers in PubMed, 1 pooled it
98.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1,129 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,647 citations in OpenAlex.
- Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.Hepatology communications · 2026Pooled it
- Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction-associated steatohepatitis.Bioactive materials · 2027Article
- Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment.Biomaterials · 2027Article
- Liver fibrosis: Pathogenesis and innovative nanoparticle-based therapeutic strategies.International journal of pharmaceutics: X · 2026Review
- Multi-omics integration deciphers arsenic-induced multi-organ toxicity and the novel ferroptosis axis.Toxicology reports · 2026Review
- Progressive suppression of regulated cell death defines terminal macrophage states in liver cirrhosis.Annals of medicine · 2026Article
- Metabolic drivers of MASLD and MASH: from hormonal imbalance to fibrosis.Diabetologia · 2026Review
- A human single-cell atlas identifies OLR1Nature genetics · 2026Article
- Excessive EFHD1-dependent ER-mitochondrial contacts drive a maladaptive antiviral response in metabolic liver disease.The Journal of clinical investigation · 2026Article
- THBS1+ macrophages fuel pathogenic inflammation in alcohol-associated liver disease.Hepatology communications · 2026Article
- Defining pathogenic macrophages in the fibrotic niche of human chronic liver disease.Nature genetics · 2026Article
- Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche to promote MASLD progression.The Journal of clinical investigation · 2026Article
- Activated hepatic stellate cell-derived exosomal miR-23a-3p promotes hepatocellular carcinogenesis by regulating DUSP5/ERK signaling.Journal of advanced research · 2026Article
- TGF-β/Smad-Associated Epithelial-Fibroblast Remodeling Underlies Collagen Deposition in Chronic Rhinosinusitis With Nasal Polyps.Immunity, inflammation and disease · 2026Article
- Omics-based Decoding of Metabolic Dysfunction-associated Fatty Liver Disease: From Pathogenesis to Clinical Translation.Journal of clinical and translational hepatology · 2026Review
- Single-cell RNA Sequencing Analysis Reveals That Targeting PLG-PLGRKT Signaling-mediated Pro-fibrotic Scar-associated Macrophages Ameliorates Liver Fibrosis in Biliary Atresia.Journal of clinical and translational hepatology · 2026Article
- Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche.Cell reports · 2026Article
- Multi-omic analysis of jaw-bone periosteum identifies the role of macrophage-derived SPP1 in CtskBone research · 2026Article
- An lncRNA-aware single-cell framework with donor-level validation identifies reproducible MEG3 enrichment in human liver sinusoidal endothelial cells.Functional & integrative genomics · 2026Article
- Macrophage heterogeneity in human secondary lymphoid organs.Clinical science (London, England : 1979) · 2026Review
1,069 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 12 institutions in 3 countries.
P RamachandranUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK. prakash.ramachandran@ed.ac.uk.
R DobieUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
J R Wilson-KanamoriUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
E F DoraUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
B E P HendersonUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
N T LuuNIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.
J R PortmanUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
K P MatchettUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
M BriceUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
J A MarwickUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
R S TaylorUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
M EfremovaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
R Vento-TormoWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
N O CarragherCancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK.
T J KendallUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
J A FallowfieldUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
E M HarrisonClinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.
D J MoleUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
S J WigmoreUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.
P N NewsomeNIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.
C J WestonNIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.
J P IredaleOffice of the Vice Chancellor, Beacon House and National Institute for Health Research, Biomedical Research Centre, Bristol, UK.
F TackeDepartment of Hepatology and Gastroenterology, Charité University Medical Center, Berlin, Germany.
J W PollardMRC Centre for Reproductive Health, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
C P PontingMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK.
J C MarioniWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
S A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
N C HendersonUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK. neil.henderson@ed.ac.uk.
The Queen's Medical Research Institute · GBUniversity of Edinburgh · GBCentre for Inflammation Research · GBMRC Institute of Genetics and Molecular Medicine · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Cambridge · GBWellcome Sanger Institute · GBCharité - Universitätsmedizin Berlin · DEEdinburgh Cancer Research · GBEdinburgh Royal Infirmary · GBNational Institute for Health Research · GBNIHR Birmingham Biomedical Research Centre · GB
Funding
British Heart Foundation RE/18/5/34216British Heart Foundation RM/17/3/33381Cancer Research UK 22231Medical Research Council G0600033Medical Research Council G1002033Medical Research Council G84/6205Medical Research Council MC_PC_15041Medical Research Council MC_PC_15049Medical Research Council MC_PC_15075Medical Research Council MC_PC_17159Medical Research Council MC_UU_00007/15Medical Research Council MC_UU_12008/1Medical Research Council MR/N008340/1Medical Research Council MR/N022556/1Medical Research Council MR/P008887/1Wellcome Trust 103749
Abstract
Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in disease pathogenesis and enable the discovery of therapeutic targets, here we profile the transcriptomes of more than 100,000 single human cells, yielding molecular definitions for non-parenchymal cell types that are found in healthy and cirrhotic human liver. We identify a scar-associated TREM2
Indexed as
Single-Cell AnalysisAnimalsCase-Control StudiesCell LineageDuffy Blood-Group SystemEndothelial CellsFemaleHepatic Stellate CellsHepatocytesHumansLiverLiver CirrhosisMacrophagesMaleMembrane GlycoproteinsMembrane ProteinsACKR1 protein, humanDuffy Blood-Group SystemMembrane GlycoproteinsMembrane ProteinsPLVAP protein, humanReceptor, Platelet-Derived Growth Factor alphaReceptors, Cell SurfaceReceptors, ImmunologicTetraspanin 29TREM2 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.