Evidence map›Paper›PMID 31596949›Full record

ArticleBritish journal of pharmacology2020

The effect of two selective A

Samantha L Cooper, Julie March, Andrea R Sabbatini, Stephen J Hill, Manuela Jörg, Peter J Scammells, Jeanette Woolard

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Regionally selective cardiovascular responses to adenosine AFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  3. The effect of two selective ABritish journal of pharmacology · 2020
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Samantha L CooperDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0002-9062-5893
Julie MarchDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.
Andrea R SabbatiniDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0003-3338-2845
Stephen J HillDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0002-4424-239X
Manuela JörgMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Peter J ScammellsMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Jeanette WoolardDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.ORCID 0000-0001-5406-6847
University of Nottingham · GBMonash University · AU

Funding

Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES)-University of Nottingham Programme in Drug Discovery Postdoctoral Fellowship 88881.141266/2017-01British Heart Foundation PG/14/95/31248Medical Research Council MR/N020081/1
6 · The paper itself

Abstract

background and purposeAdenosine is a local mediator that regulates physiological and pathological processes via activation of four GPCRs (A EXPERIMENTAL APPROACH: The regional haemodynamic responses of these agonist was investigated in conscious rats. Male Sprague-Dawley rats (350-450 g) were chronically implanted with pulsed Doppler flow probes on the renal, mesenteric arteries and the descending abdominal aorta and the jugular vein and caudal artery catheterized. Cardiovascular responses were measured following intravenous infusion (3 min each dose) of CCPA (120, 400, and 1,200 ng·kg KEY

resultsCCPA produced a significant A CONCLUSIONS AND IMPLICATIONS: These results suggest VCP746 mediates its cardiovascular effects via activation of A

Indexed as

AdenosineAdenosine A1 Receptor AgonistsAdenosine A2 Receptor AgonistsAminopyridinesAnimalsCardiovascular SystemConsciousnessDrug Partial AgonismHeart RateHemodynamicsLigandsMaleRats, Sprague-DawleyReceptor, Adenosine A1Receptor, Adenosine A2AReceptor, Adenosine A2B2-chloro-N(6)cyclopentyladenosineAdenosineAdenosine A1 Receptor AgonistsAdenosine A2 Receptor AgonistsAdora2b protein, ratAminopyridinescapadenosonLigandsReceptor, Adenosine A1Receptor, Adenosine A2AReceptor, Adenosine A2BThiazolesThiophenesVCP746

Identifiers

PMID31596949
PMCPMC6989947
OpenAlexW2979940954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.