ArticlePloS one2019
Clade II Candida auris possess genomic structural variations related to an ancestral strain.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Updated Genomic Epidemiologic Description of Candida (Candidozyma) auris, United States.Emerging infectious diseases · 2026Article
- We Are Family: Comparative Study ofPathogens (Basel, Switzerland) · 2026Article
- Fatty Acid Profiling Identification Method of Emerging Fungal PathogenJournal of fungi (Basel, Switzerland) · 2026Article
- Genomic Insights intoJournal of fungi (Basel, Switzerland) · 2026Article
- Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance.Nature communications · 2025Article
- Global Stress Responses Identify the Functionally Divergent Regulators Required forExploration (Beijing, China) · 2025Article
- A study of genomic complexity underlying multidrug resistance in Candida auris strains in Thailand.Scientific reports · 2025Article
- Genomics insights of candidiasis: mechanisms of pathogenicity and drug resistance.Frontiers in microbiology · 2025Review
- Application of Raman spectroscopy and machine learning forApplied and environmental microbiology · 2024Article
- Complete genome assembly ofMicrobiology resource announcements · 2024Article
- Review
- Recent gene selection and drug resistance underscore clinical adaptation across Candida species.Nature microbiology · 2024Article
- Emerging Antifungal Resistance in Fungal Pathogens.Current clinical microbiology reports · 2024Review
- Antifungal Activity of the Dichloromethane Extract of CaoHuangGuiXiang Formula AgainstInfection and drug resistance · 2024Article
- Evaluation of a NovelJournal of fungi (Basel, Switzerland) · 2023Article
- Functional Expression of RecombinantJournal of fungi (Basel, Switzerland) · 2023Article
- Candida auris: a novel emerging nosocomial pathogen - properties, epidemiological situation and infection control.GMS hygiene and infection control · 2023Article
- Candidiasis and Other Emerging Yeasts.Current fungal infection reports · 2023Review
- Article
- Confirmation of fifthEmerging microbes & infections · 2022Article
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8 authors.
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Abstract
Candida auris is an invasive and multidrug-resistant ascomycetous yeast that is under global surveillance. All clinical cases of C. auris infection diagnosed from 1997 to 2019 in Japan were non-invasive and sporadic otitis media cases. In the present study, we performed whole-genome sequencing of seven C. auris strains isolated from patients with otitis media in Japan, all of which belonged to clade II. Comparative genome analysis using the high-quality draft genome sequences JCM 15448T revealed that single nucleotide variations (SNVs), clade-specific accessory genes, and copy number variations (CNVs) were identified in each C. auris clade. A total of 61 genes involved in cell wall and stress response-related functions was absent in clade II, and the pattern of conserved CNVs in each clade was more stable in clade II than in other clades. Our data suggest that the genomic structural diversity is stable in C. auris isolated from each biogeographic location, and Japanese strains isolated from patients with otitis media might belong to an ancestral type of C. auris. One Japanese strain, TWCC 58362, with reduced susceptibility to fluconazole, exhibited no mutation in ergosterol biosynthesis-related genes (ERG). However, TWCC 58362-specific variations, including SNVs, indels, and CNVs were detected, suggesting that gene duplication events in C. auris might contribute to antifungal drug resistance. Taken together, we demonstrated that genomic structural variations in C. auris could correlate to geographical dissemination, epidemiology, lesions in the host, and antifungal resistance.
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