Evidence map›Paper›PMID 31596653›Full record

ArticleJournal of neurophysiology2019

GABA

Erica L Littlejohn, Liliana Espinoza, Monica M Lopez, Bret N Smith, Carie R Boychuk

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Neuropsychiatric Lyme Disease and Vagus Nerve Stimulation.Antibiotics (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Sex-steroid-dependent plasticity of brain-stem autonomic circuits.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Erica L LittlejohnDepartment of Cellular and Integrative Physiology, College of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Liliana EspinozaDepartment of Cellular and Integrative Physiology, College of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Monica M LopezDepartment of Cellular and Integrative Physiology, College of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Bret N SmithDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky.
Carie R BoychukDepartment of Cellular and Integrative Physiology, College of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
The University of Texas Health Science Center at San Antonio · USUniversity of Kentucky · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
Neural Circuitry in the Dorsal Vagal ComplexR01DK056132 · NIDDK · UNIVERSITY OF KENTUCKY · PI SMITH, BRET N · 2001 to 2019
$4.9M
Recruiting and Retaining URM StudentsR25GM095480 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI OYAJOBI, BABATUNDE OLUKAYODE, WEISS, DAVID S · 2011 to 2021
$3.4M
NCATS NIH HHS UL1 TR001998NHLBI NIH HHS T32 HL007446NIDDK NIH HHS R01 DK056132NIGMS NIH HHS R25 GM095480
6 · The paper itself

Abstract

The dorsal motor nucleus of the vagus (DMV) contains the preganglionic motor neurons important in the regulation of glucose homeostasis and gastrointestinal function. Despite the role of sex in the regulation of these processes, few studies examine the role of sex and/or ovarian cycle in the regulation of synaptic neurotransmission to the DMV. Since GABAergic neurotransmission is critical to normal DMV function, the present study used in vitro whole cell patch-clamping to investigate whether sex differences exist in GABAergic neurotransmission to DMV neurons. It additionally investigated whether the ovarian cycle plays a role in those sex differences. The frequency of phasic GABA

Indexed as

Sex Characteristics3-Oxo-5-alpha-Steroid 4-Dehydrogenase5-alpha Reductase InhibitorsAnimalsEstrogensFemalegamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsMaleMenstrual CycleMiceMotor NeuronsNeuronal PlasticityOvariectomyPatch-Clamp TechniquesReceptors, GABA-A3-Oxo-5-alpha-Steroid 4-Dehydrogenase5-alpha Reductase InhibitorsEstrogensgamma-Aminobutyric AcidReceptors, GABA-AdiestruselectrophysiologyGABAneurosteroidovarian cyclevagus

Identifiers

PMID31596653
PMCPMC6879959
OpenAlexW2980058219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.