Evidence map›Paper›PMID 31596583›Full record

ArticleJournal of medicinal chemistry2019

Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators.

Thuy Nguyen, Thomas F Gamage, Ann M Decker, Daniel Barrus, Tiffany L Langston, Jun-Xu Li, Brian F Thomas, Yanan Zhang

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thuy NguyenResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Thomas F GamageResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Ann M DeckerResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Daniel BarrusResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Tiffany L LangstonResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Jun-Xu LiDepartment of Pharmacology and Toxicology , University of Buffalo, the State University of New York , Buffalo , New York 14214 , United States.ORCID 0000-0001-8103-7013
Brian F ThomasResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.
Yanan ZhangResearch Triangle Institute , Research Triangle Park , North Carolina 27709 , United States.ORCID 0000-0001-7153-4358
RTI International · USUniversity at Buffalo, State University of New York · US

Funding

Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
Allosteric Modulation of the CB1 ReceptorR01DA040693 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI ZHANG, YANAN · 2016 to 2020
$2.4M
In vitro and in vivo characterization of CB1 allosteric modulatorsK01DA045752 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2018 to 2022
$807k
NIDA NIH HHS K01 DA045752NIDA NIH HHS R01 DA040460NIDA NIH HHS R01 DA040693
6 · The paper itself

Abstract

We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB

Indexed as

Allosteric RegulationChemistry Techniques, SyntheticCyclic AMPHEK293 CellsHumansPhenylurea CompoundsReceptor, Cannabinoid, CB1Structure-Activity RelationshipCyclic AMPPhenylurea CompoundsReceptor, Cannabinoid, CB1

Identifiers

PMID31596583
PMCPMC6953423
OpenAlexW2980020770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.