ArticleAngewandte Chemie (International ed. in English)2019
A Single Thermoresponsive Diblock Copolymer Can Form Spheres, Worms or Vesicles in Aqueous Solution.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Thermoreversibly assembled polymersomes for highly efficient loading, processing and delivery of protein and siRNA biologics.Nature biomedical engineering · 2026Article
- Amphiphilic polymer conetworks based on triPEG and tetraPEG end-linked multi-armed star block copolymers.Science and technology of advanced materials · 2026Article
- Polymersome-based nanomotors: preparation, motion control, and biomedical applications.Chemical science · 2025Review
- Microfluidic Controlled Self-Assembly of Polylactide (PLA)-Based Linear and Graft Copolymers into Nanoparticles with Diverse Morphologies.ACS polymers Au · 2024Article
- pH-Responsive Nanogels Generated by Polymerization-Induced Self-Assembly of a Succinate-Functional Monomer.Macromolecules · 2024Article
- Block copolymer synthesis in ionic liquidChemical science · 2024Article
- Thermoresponsive Poly(Biomacromolecules · 2023Article
- Continuous-Flow Laboratory SAXS for In Situ Determination of the Impact of Hydrophilic Block Length on Spherical Nano-Object Formation during Polymerization-Induced Self-Assembly.Macromolecules · 2023Article
- Interpretable Machine Learning Models for Phase Prediction in Polymerization-Induced Self-Assembly.Journal of chemical information and modeling · 2023Article
- Article
- Polymerization-Induced Self-Assembly for Efficient Fabrication of Biomedical Nanoplatforms.Research (Washington, D.C.) · 2023Review
- Silica nanoparticle-loaded thermoresponsive block copolymer vesicles: a new post-polymerization encapsulation strategy and thermally triggered release.Chemical science · 2022Article
- Reverse Sequence Polymerization-Induced Self-Assembly in Aqueous Media.Angewandte Chemie (International ed. in English) · 2022Article
- Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s.Polymer chemistry · 2022Article
- Polymerization-induced self-assembly and disassembly during the synthesis of thermoresponsive ABC triblock copolymer nano-objects in aqueous solution.Chemical science · 2022Article
- Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion.Chemical science · 2022Article
- Synthesis of Thermoresponsive Diblock Copolymer Nano-Objects via RAFT Aqueous Emulsion Polymerization of Hydroxybutyl Methacrylate.Macromolecules · 2022Article
- RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions.Chemical science · 2022Review
- Transformer-Induced Metamorphosis of Polymeric Nanoparticle Shape at Room Temperature.Angewandte Chemie (International ed. in English) · 2022Article
- Reversible Addition-Fragmentation Chain Transfer Aqueous Dispersion Polymerization of 4-Hydroxybutyl Acrylate Produces Highly Thermoresponsive Diblock Copolymer Nano-Objects.Macromolecules · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
It is well-known that the self-assembly of AB diblock copolymers in solution can produce various morphologies depending on the relative volume fraction of each block. Recently, polymerization-induced self-assembly (PISA) has become widely recognized as a powerful platform technology for the rational design and efficient synthesis of a wide range of block copolymer nano-objects. In this study, PISA is used to prepare a new thermoresponsive poly(N-(2-hydroxypropyl) methacrylamide)-poly(2-hydroxypropyl methacrylate) [PHPMAC-PHPMA] diblock copolymer. Remarkably, TEM, rheology and SAXS studies indicate that a single copolymer composition can form well-defined spheres (4 °C), worms (22 °C) or vesicles (50 °C) in aqueous solution. Given that the two monomer repeat units have almost identical chemical structures, this system is particularly well-suited to theoretical analysis. Self-consistent mean field theory suggests this rich self-assembly behavior is the result of the greater degree of hydration of the PHPMA block at lower temperature, which is in agreement with variable temperature
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.