ArticleToxicological sciences : an official journal of the Society of Toxicology2020
Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Article
- Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives.Archives of toxicology · 2024Article
- Bisphenol F and Bisphenol S in a Complex Biomembrane: Comparison with Bisphenol A.Journal of xenobiotics · 2024Article
- Artificial intelligence (AI)-it's the end of the tox as we know it (and I feel fine).Archives of toxicology · 2024Review
- Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network.Archives of toxicology · 2024Article
- Application of AOPs to assist regulatory assessment of chemical risks - Case studies, needs and recommendations.Environmental research · 2023Review
- Daphnia as a model organism to probe biological responses to nanomaterials-from individual to population effects via adverse outcome pathways.Frontiers in toxicology · 2023Review
- An integrative systems biology strategy to support the development of adverse outcome pathways (AOPs): a case study on radiation-induced microcephaly.Frontiers in cell and developmental biology · 2023Article
- Review
- Article
- A Narrative Literature Review of Natural Language Processing Applied to the Occupational Exposome.International journal of environmental research and public health · 2022Review
- Integration strategy of network pharmacology in Traditional Chinese Medicine: a narrative review.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Review
- Obesity III: Obesogen assays: Limitations, strengths, and new directions.Biochemical pharmacology · 2022Review
- The Exposome and Toxicology: A Win-Win Collaboration.Toxicological sciences : an official journal of the Society of Toxicology · 2022Review
- Emerging Bioinformatics Methods and Resources in Drug Toxicology.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Review
- Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework.International journal of radiation biology · 2021Article
- Capturing a Comprehensive Picture of Biological Events From Adverse Outcome Pathways in the Drug Exposome.Frontiers in public health · 2021Article
- Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities.Frontiers in toxicology · 2021Article
- AOP4EUpest: mapping of pesticides in adverse outcome pathways using a text mining tool.Bioinformatics (Oxford, England) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol F (BPF) is one of several Bisphenol A (BPA) substituents that is increasingly used in manufacturing industry leading to detectable human exposure. Whereas a large number of studies have been devoted to decipher BPA effects, much less is known about its substituents. To support decision making on BPF's safety, we have developed a new computational approach to rapidly explore the available data on its toxicological effects, combining text mining and integrative systems biology, and aiming at connecting BPF to adverse outcome pathways (AOPs). We first extracted from different databases BPF-protein associations that were expanded to protein complexes using protein-protein interaction datasets. Over-representation analysis of the protein complexes allowed to identify the most relevant biological pathways putatively targeted by BPF. Then, automatic screening of scientific abstracts from literature using the text mining tool, AOP-helpFinder, combined with data integration from various sources (AOP-wiki, CompTox, etc.) and manual curation allowed us to link BPF to AOP events. Finally, we combined all the information gathered through those analyses and built a comprehensive complex framework linking BPF to an AOP network including, as adverse outcomes, various types of cancers such as breast and thyroid malignancies. These results which integrate different types of data can support regulatory assessment of the BPA substituent, BPF, and trigger new epidemiological and experimental studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.