Evidence map›Paper›PMID 31596280›Full record

ArticleChemical communications (Cambridge, England)2019

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators.

Manuel González-Cuesta, David Goyard, Eiji Nanba, Katsumi Higaki, José M García Fernández, Olivier Renaudet, Carmen Ortiz Mellet

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Cyclodextrin-Based Functional Glyconanomaterials.Nanomaterials (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Manuel González-CuestaDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain. mellet@us.es.ORCID http://orcid.org/0000-0003-2778-9489
David GoyardUniversité Grenoble Alpes, CNRS, DCM UMR 5250, 3800 Grenoble, France. olivier.renaudet@univ-grenoble-alpes.fr.ORCID http://orcid.org/0000-0002-6410-0866
Eiji NanbaOrganization for Research Initiative and Promotion, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan.
Katsumi HigakiOrganization for Research Initiative and Promotion, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan.
José M García FernándezInstituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Avda. Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain. jogarcia@iiq.csic.es.ORCID http://orcid.org/0000-0002-6827-0387
Olivier RenaudetUniversité Grenoble Alpes, CNRS, DCM UMR 5250, 3800 Grenoble, France. olivier.renaudet@univ-grenoble-alpes.fr and Institut Universitaire de France, 103 Boulevard Saint-Michel, 75005 Paris, France.ORCID http://orcid.org/0000-0003-4963-3848
Carmen Ortiz MelletDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain. mellet@us.es.ORCID http://orcid.org/0000-0002-7676-7721
Centre National de la Recherche Scientifique · FRFaculty (United Kingdom) · GBNational Institute of Technology, Yonago College · JPCentro de Investigaciones Científicas Isla de la Cartuja · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal β-glucocerebrosidase or α-mannosidase depending on valency and topology, offering new opportunities in multitargeted drug design.

Indexed as

Drug Designalpha-Mannosidasebeta-CyclodextrinsGlucosylceramidaseLectinsMacrophagesMannosidesPeptides, Cyclicalpha-Mannosidasebeta-CyclodextrinsbetadexGlucosylceramidaseLectinsMannosidesPeptides, Cyclic

Identifiers

PMID31596280
PMCPMC12954580
OpenAlexW2977949239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.