Evidence map›Paper›PMID 31596236›Full record

ArticleeLife2019

Mitochondrial fusion is required for spermatogonial differentiation and meiosis.

Grigor Varuzhanyan, Rebecca Rojansky, Michael J Sweredoski, Robert L J Graham, Sonja Hess, Mark S Ladinsky, David C Chan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
  2. Article
  3. PSMA8-Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Grigor VaruzhanyanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID https://orcid.org/0000-0001-6165-0857
Rebecca RojanskyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Michael J SweredoskiProteome Exploration Laboratory of the Beckman Institute, California Institute of Technology, Pasadena, United States.ORCID http://orcid.org/0000-0003-0878-3831
Robert L J GrahamProteome Exploration Laboratory of the Beckman Institute, California Institute of Technology, Pasadena, United States.
Sonja HessProteome Exploration Laboratory of the Beckman Institute, California Institute of Technology, Pasadena, United States.
Mark S LadinskyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
David C ChanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID https://orcid.org/0000-0002-0191-2154
California Institute of Technology · US

Funding

PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
Virus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI HOPE, THOMAS · 2019 to 2021
$14.9M
Homeostatic Mechanisms Regulating Mitochondrial Health EQUIPMENT SUPPLEMENTR35GM127147 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI David C Chan · 2018 to 2026
$6.0M
Analysis of Fis1 in Mitophagy in MammalsR01GM119388 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHAN, DAVID C · 2016 to 2018
$1.5M
Gordon and Betty Moore Foundation GBMF775National Science Foundation Graduate Research Fellowship (DGE-1144469)NIAID NIH HHS P50 AI150464NIGMS NIH HHS R01 GM119388NIGMS NIH HHS R35 GM127147NIGMS NIH HHS T32 GM007616NIH HHS Cell and Molecular Biology Training Grant (GM07616T32)NIH HHS GM119388NIH HHS R35 GM127147
6 · The paper itself

Abstract

Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis. Acutely after depletion of mitofusins

Indexed as

Cell DifferentiationMeiosisMitochondrial DynamicsAnimalsGTP PhosphohydrolasesMaleMiceSpermatogoniaGTP PhosphohydrolasesMfn1 protein, mouseMfn2 protein, mousecell biologydevelopmental biologymembrane fusionmetabolismmitochondriamousespermatogenesis

Identifiers

PMID31596236
PMCPMC6805159
OpenAlexW2979348022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.