Evidence map›Paper›PMID 31596203›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019

Temporal Association Between Respiratory Events and Reflux in Patients With Obstructive Sleep Apnea and Laryngopharyngeal Reflux.

Sandra Doria Xavier, Claudia Alessandra Eckley, André Campos Duprat, Luiz Henrique de Souza Fontes, Tomás Navarro-Rodriguez, Julio Patrocínio, Daniela Tridente, Geraldo Lorenzi-Filho

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In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Association between oropharyngeal ph-monitoring, pepsin saliva concentration and degree of apnea-hypopnea index of obstructive sleep apnea.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023
    Article
  3. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
  4. Laryngopharyngeal Reflux in Sleep-Disordered Breathing Patients.Iranian journal of otorhinolaryngology · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sandra Doria XavierOtolaryngology Department,Santa Casa São Paulo, São Paulo, Brazil.
Claudia Alessandra EckleyOtolaryngology Department,Santa Casa São Paulo, São Paulo, Brazil.
André Campos DupratOtolaryngology Department,Santa Casa São Paulo, São Paulo, Brazil.
Luiz Henrique de Souza FontesEsophagus and Digestive Motility of Gastroenterology, Department of Hospital Clínicas, São Paulo University, São Paulo, Brazil.
Tomás Navarro-RodriguezEsophagus and Digestive Motility of Gastroenterology, Department of Hospital Clínicas, São Paulo University, São Paulo, Brazil.
Julio PatrocínioHead and Neck Department, Santa Casa São Paulo, São Paulo, Brazil.
Daniela TridenteBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Geraldo Lorenzi-FilhoInCor Sleep Center Laboratory Director, São Paulo, Brazil.
Santa Casa Hospital · BRHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesThe aim of the current study was to test the hypothesis that there is a temporal correlation between reflux episodes and respiratory events in patients with laryngopharyngeal reflux and obstructive sleep apnea.

methodsAdults with clinically diagnosed laryngopharyngeal reflux confirmed by two validated instruments (reflux symptom index ≥ 13 and reflux finding score ≥ 7) and obstructive sleep apnea (OSA) underwent full polysomnography with concomitant and synchronized multichannel intraluminal impedance-pH esophageal monitoring. The apnea-hypopnea and arousal indexes that occurred 15, 30, and 45 minutes before and after each reflux episode were recorded and compared to full-night apnea and hypopnea and arousal index.

resultsWe studied 27 patients (14 males, age 51.7 ± 9.1 years, body mass index 32.4 ± 4.2 kg/m²) with laryngopharyngeal reflux (reflux symptom index 16 ± 2 and reflux finding score 12 ± 3) and OSA (apnea-hypopnea index = 32.3 ± 28.4 events/h). We evaluated 102 reflux episodes. Almost half of the reflux episodes occurred while awake (43.1%) and only five reflux episodes (4.9%) occurred during an obstructive respiratory event. The apnea and hypopnea and arousal indexes 15, 30, and 45 minutes before and after reflux episodes were lower than full-night apnea and hypopnea and arousal indexes, respectively.

conclusionsAmong patients with well-established laryngopharyngeal reflux and OSA, there is no temporal association between reflux and obstructive respiratory events. Even though the data comprised a small sample size, it seems that a more complex mechanism is involved with these two highly prevalent diseases.

Indexed as

EsophagusFemaleHumansLaryngopharyngeal RefluxMaleMiddle AgedPolysomnographySleep Apnea, ObstructiveTimegastroesophageal refluxlaryngopharyngeal refluxpH impedancesleep apnea syndrome

Identifiers

PMID31596203
PMCPMC6778358
OpenAlexW2980776898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.