Observational studyAmerican journal of epidemiology2019
Incidence of Initial Renal Replacement Therapy Over the Course of Kidney Disease in Children.
Observational study in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Risk factors for chronic kidney disease progression in VACTERL-association Korean patients: a retrospective study.Childhood kidney diseases · 2026Article
- Cross-Population Validation of the Pediatric CKD Risk-Prediction Tool.Kidney international reports · 2026Article
- Dual knowledge-guided data augmentation for robust clinical prediction models.Scientific reports · 2026Article
- Anemia Management in Pediatric Chronic Kidney Disease: Current Challenges and Treatment Strategies.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Review
- Social Deprivation and Incidence of Pediatric Kidney Failure in France.Kidney international reports · 2024Article
- Preparing for kidney replacement therapy in pediatric advanced CKD: a review of literature and defining a multi-disciplinary clinical approach to patient-caregiver education.Pediatric nephrology (Berlin, Germany) · 2023Review
- Trajectories of eGFR after kidney transplantation according to trajectories of eGFR prior to kidney replacement therapies in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Development of an adaptive clinical web-based prediction tool for kidney replacement therapy in children with chronic kidney disease.Kidney international · 2023Article
- Data quality control in longitudinal epidemiologic studies: conditional studentized residuals from linear mixed effects models for outlier detection in the setting of pediatric chronic kidney disease.Annals of epidemiology · 2023Article
- Development of a Family-Centered Communication Tool for Kidney Health in Premature Infants: Qualitative Focus Group Study Using Human-Centered Design Methodology.Journal of participatory medicine · 2023Article
- Revisiting the Application of an Adult Kidney Failure Risk Prediction Equation to Children With CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- The Relationship Between Neighborhood Disadvantage and Kidney Disease Progression in the Chronic Kidney Disease in Children (CKiD) Cohort.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Observational
- Kidney Disease Progression in Children and Young Adults With Pediatric CKD: Epidemiologic Perspectives and Clinical Applications.Seminars in nephrology · 2021Review
- Mean Arterial Pressure and Chronic Kidney Disease Progression in the CKiD Cohort.Hypertension (Dallas, Tex. : 1979) · 2021Observational
- Alcohol, cigarette, e-cigarette and marijuana use among adolescents and young adults with chronic kidney disease in North America.Annals of epidemiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The Chronic Kidney Disease in Children Study, a prospective cohort study with data collected from 2003 to 2018, provided the first opportunity to characterize the incidence of renal replacement therapy (RRT) initiation over the life course of pediatric kidney diseases. In the current analysis, parametric generalized gamma models were fitted and extrapolated for RRT overall and by specific treatment modality (dialysis or preemptive kidney transplant). Children were stratified by type of diagnosis: nonglomerular (mostly congenital; n = 650), glomerular-hemolytic uremic syndrome (HUS; n = 49), or glomerular-non-HUS (heterogeneous childhood onset; n = 216). Estimated durations of time to RRT after disease onset for 99% of the nonglomerular and glomerular-non-HUS groups were 42.5 years (95% confidence interval (CI): 31.0, 54.1) and 25.4 years (95% CI: 14.9, 36.0), respectively. Since onset for the great majority of children in the nonglomerular group was congenital, disease duration equated with age. A simulation-based estimate of age at RRT for 99% of the glomerular population was 37.9 years (95% CI: 33.6, 63.2). These models performed well in cross-validation. Children with glomerular disease received dialysis earlier and were less likely to have a preemptive kidney transplant, while the timing and proportions of dialysis and transplantation were similar for the nonglomerular group. These diagnosis-specific estimates provide insight into patient-centered prognostic information and can assist in RRT planning efforts for children with moderate-to-severe kidney disease who are receiving regular specialty care.
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Registered trials
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