ArticleJournal of Zhejiang University. Science. B
Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein.
Article in Journal of Zhejiang University. Science. B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- Influence of phloretin on acrolein-induced protein modification and physicochemical changes in a dairy protein model.Food chemistry: X · 2024Article
- Biochar-Mediated Control of Metabolites and Other Physiological Responses in Water-StressedMetabolites · 2023Article
- Origin and Fate of Acrolein in Foods.Foods (Basel, Switzerland) · 2022Review
- Effect of resveratrol treatment on apoptosis and apoptotic pathways during boar semen freezing.Journal of Zhejiang University. Science. B · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
Acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is focused on the scavenging abilities and mechanism of ferulic acid and some other phenolic acids against acrolein. Among the 13 phenolic compounds investigated, ferulic acid was found to have the highest efficiency in scavenging acrolein under physiological conditions. Ferulic acid remained at (3.04±1.89)% and acrolein remained at (29.51±4.44)% after being incubated with each other for 24 h. The molecular mechanism of the detoxifying process was also studied. Detoxifying products, namely 2-methoxy-4-vinylphenol (product 21) and 5-(4-hydroxy-3-methoxyphenyl)pent-4-enal (product 22), were identified though nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS), after the scavenging process. Ferulic acid showed significant activity in scavenging acrolein under physiological conditions. This study indicates a new method for inhibiting damage from acrolein.
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