Evidence map›Paper›PMID 31595626›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Bioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical Polymerization.

Hao Sun, Wonmin Choi, Nanzhi Zang, Claudia Battistella, Matthew P Thompson, Wei Cao, Xuhao Zhou, Christopher Forman, Nathan C Gianneschi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  7. Article
  8. Review
  9. Light: A Magical Tool for Controlled Drug Delivery.Advanced functional materials · 2020
    Article
  10. Review
  11. Article
  12. Progress and Perspectives Beyond Traditional RAFT Polymerization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hao SunDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID 0000-0001-9153-4021
Wonmin ChoiDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Nanzhi ZangDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Claudia BattistellaDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Matthew P ThompsonDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Wei CaoDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID 0000-0002-5048-7991
Xuhao ZhouDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Christopher FormanDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Nathan C GianneschiDepartment of Chemistry, Materials Science & Engineering, Biomedical Engineering, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute and the Lurie Cancer Center, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID 0000-0001-9945-5475

Funding

MMP responsive polymeric materials for treating acute myocardial infarctionR01HL139001 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Karen L Christman, Nathan Claude Gianneschi · 2017 to 2026
$3.9M
Autonomously Assembling Nanomaterial Scaffolds for Treating Myocardial InfarctionR01HL117326 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTMAN, KAREN L, GIANNESCHI, NATHAN CLAUDE · 2012 to 2016
$1.9M
Air Force Office of Scientific Research FA9550-16-1-0150National Science Foundation DMR-1710105NHLBI NIH HHS R01 HL117326NHLBI NIH HHS R01 HL139001
6 · The paper itself

Abstract

Harnessing metal-free photoinduced reversible-deactivation radical polymerization (photo-RDRP) in organic and aqueous phases, we report a synthetic approach to enzyme-responsive and pro-apoptotic peptide brush polymers. Thermolysin-responsive peptide-based polymeric amphiphiles assembled into spherical micellar nanoparticles that undergo a morphology transition to worm-like micelles upon enzyme-triggered cleavage of coronal peptide sidechains. Moreover, pro-apoptotic polypeptide brushes show enhanced cell uptake over individual peptide chains of the same sequence, resulting in a significant increase in cytotoxicity to cancer cells. Critically, increased grafting density of pro-apoptotic peptides on brush polymers correlates with increased uptake efficiency and concurrently, cytotoxicity. The mild synthetic conditions afforded by photo-RDRP, make it possible to access well-defined peptide-based polymer bioconjugate structures with tunable bioactivity.

Indexed as

MicellesAcrylatesAmino AcidsCell Membrane PermeabilityCell SurvivalFree RadicalsHeLa CellsHumansMolecular ConformationNanoparticlesPeptidesPhotochemical ProcessesPolymerizationPolymersPolymethyl MethacrylateSolventsAcrylatesAmino AcidsFree RadicalsMicellesPeptidespoly(butyl acrylate)-b-poly(acrylic acid)PolymersPolymethyl MethacrylateSolventsThermolysinbiomaterialsnanomaterialspeptide brush polymerphotochemistrypolymerization

Identifiers

PMID31595626
PMCPMC7299178

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.