Evidence map›Paper›PMID 31595439›Full record

ArticleMolecular biology reports2020

Psychiatric disorders and SLC6A4 gene variants: possible effects on alcohol dependence and alzheimer's disease.

Marco Calabrò, Laura Mandelli, Concetta Crisafulli, Stefano Porcelli, Diego Albani, Antonis Politis, George N Papadimitriou, Marco Di Nicola, Luigi Janiri, Roberto Colombo and 9 more

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Frontiers in microbiology · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 4 countries.

Marco CalabròDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Laura MandelliDepartment of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy.
Concetta CrisafulliDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Stefano PorcelliDepartment of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy.
Diego AlbaniLaboratory of Biology of Neurodegenerative Disorders, Neuroscience Department, Istituto di Ricerche Farmacologiche Mario Negri IRCSS, Milan, Italy.
Antonis PolitisDepartment of Psychiatry, University of Athens Medical School, Eginition Hospital, Athens, Greece.
George N PapadimitriouDepartment of Psychiatry, University of Athens Medical School, Eginition Hospital, Athens, Greece.
Marco Di NicolaFondazione Policlinico Universitario "A. Gemelli" - IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Luigi JaniriFondazione Policlinico Universitario "A. Gemelli" - IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Roberto ColomboFondazione Policlinico Universitario "A. Gemelli" - IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Giovanni MartinottiDepartment of Neuroscience, Imaging and Clinical Sciences, University "G. d'Annunzio" of Chieti, Chieti, Italy.
Antonello BellomoPsychiatry Unit, Department of Medical Sciences, University of Foggia, Foggia, Italy.
Eduard VietaBipolar Disorders Unit, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Stefano BonassiUnit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Rome, Italy, and Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Rome, Italy.
Alessandra FrustaciBarnet, Enfield and Haringey Mental Health NHS Trust, St.Ann's Hospital, St.Ann's Road, London, N15 3 TH, UK.
Giuseppe DucciMental Health Department, ASL Roma 1, Rome, Italy.
Stefano LandiDipartimento di Biologia, Università di Pisa, Pisa, Italy.
Stefania BocciaSection of Hygiene, Institute of Public Health, Universita' Cattolica del Sacro Cuore, Fondazione Policlinico "Agostino Gemelli" IRCCS, Rome, Italy.
Alessandro SerrettiDepartment of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy. alessandro.serretti@unibo.it.ORCID http://orcid.org/0000-0003-4363-3759
Università Cattolica del Sacro Cuore · ITUniversity of Bologna · ITNational and Kapodistrian University of Athens · GRUniversity of Messina · ITASL Roma · ITBarnet Enfield and Haringey Mental Health Trust · GBCentro de Investigación Biomédica en Red de Salud Mental · ESIstituti di Ricovero e Cura a Carattere Scientifico · ITMario Negri Institute for Pharmacological Research · ITUniversity of Chieti-Pescara · ITUniversity of Foggia · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotoninergic system is one of the most important neurotransmission systems investigated in the field of psychiatry. Extensive evidence reveals how alterations of this system, and especially of the SLC6A4 gene, may be associated with psychiatric disorders. In this study we aimed to evaluate the pleiotropic nature of SLC6A4 alterations and their association with the overall risk of brain diseases rather than disorder-specific. SLC6A4 variants, namely 5HTTLPR, STin2, rs2066713, rs25531, rs4251417, rs6354 and rs7224199 were investigated in 4 independent cohorts of subjects with specific psychiatric disorders, including Alcohol dependence disorder (ALC), Alzheimer disease (ALZ), Schizophrenia (SCZ) and Bipolar disorder (BPD). Other variables (biochemical parameters and Psychiatric scales scores) were also tested for association. SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p

Indexed as

Polymorphism, GeneticAdolescentAdultAgedAged, 80 and overAlcoholismAlzheimer DiseaseCase-Control StudiesCohort StudiesComorbidityGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeGreeceHumansSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanAlcohol dependence disorderAlzheimer’s diseaseBipolar disorderGeneticsSchizophreniaSLC6A4

Identifiers

PMID31595439
OpenAlexW2979972384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.