Evidence map›Paper›PMID 31595436›Full record

ArticleInfection2019

Active surveillance of antibiotic resistance patterns in urinary tract infections in primary care in Switzerland.

Andreas Plate, Andreas Kronenberg, Martin Risch, Yolanda Mueller, Stefania Di Gangi, Thomas Rosemann, Oliver Senn

Abstract read
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In one paragraph

Article in Infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andreas PlateInstitute of Primary Care, University and University Hospital of Zurich, Pestalozzistrasse 24, 8091, Zurich, Switzerland. andreas.plate@usz.ch.ORCID http://orcid.org/0000-0001-6143-5479
Andreas KronenbergSwiss Center for Antibiotic Resistance, Institute for Infectious Diseases, University Bern, Bern and Medix General Practice Network, Bern, Switzerland.
Martin RischLabormedizinisches zentrum Dr Risch Ostschweiz AG, Buchs, St. Gallen, Switzerland.
Yolanda MuellerDepartment of Family Medicine, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Stefania Di GangiInstitute of Primary Care, University and University Hospital of Zurich, Pestalozzistrasse 24, 8091, Zurich, Switzerland.
Thomas RosemannInstitute of Primary Care, University and University Hospital of Zurich, Pestalozzistrasse 24, 8091, Zurich, Switzerland.
Oliver SennInstitute of Primary Care, University and University Hospital of Zurich, Pestalozzistrasse 24, 8091, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUrinary tract infections (UTI) are one of the most common reasons for prescribing antibiotics in primary care. In Switzerland, the Swiss Center for Antibiotic Resistances (ANRESIS) provides resistance data by passive surveillance, which overestimates the true resistance rates. The aim of this study was to provide actual data of the antimicrobial resistance patterns in patients with UTI in Swiss primary care.

methodsFrom June 2017 to August 2018, we conducted a cross-sectional study in 163 practices in Switzerland. We determined the resistance patterns of uropathogens in patients with a diagnosis of a lower UTI and analyzed risk factors for resistance. Patients with age < 18 years, pregnancy or a pyelonephritis were excluded.

results1352 patients (mean age 53.8, 94.9% female) were included in the study. 1210 cases (89.5%) were classified as uncomplicated UTI. Escherichia coli (E. coli) was the most frequent pathogen (74.6%). Susceptibility proportions of E. coli to ciprofloxacin (88.9%) and trimethoprim-sulfamethoxazol (TMP/SMX) (85.7%) were significantly higher than the proportions reported by ANRESIS. We found high susceptibility to the recommended first-line antibiotics nitrofurantoin (99.5%) and fosfomycin (99.4%). Increasing age, antimicrobial exposure and a recent travel history were independently associated with resistance. DISCUSSION: In this study, we report actual data on the resistance patterns of uropathogens in primary care in Switzerland. Escherichia coli showed low resistance rates to the recommended first-line antibiotics. Resistance to TMP/SMX was significantly lower than reported by ANRESIS, making TMP/SMX a suitable and cheap alternative for the empirical treatment.

Indexed as

Drug Resistance, BacterialWatchful WaitingAdultAgedAged, 80 and overAnti-Bacterial AgentsBacteriaCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalencePrimary Health CareSwitzerlandUrinary Tract InfectionsAnti-Bacterial AgentsE. coliPrimary careResistance ratesSusceptibility ratesSwitzerlandUrinary tract infection

Identifiers

PMID31595436

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.