Evidence map›Paper›PMID 31595396›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2020

Immunohistochemical analysis of tumor budding as predictor of lymph node metastasis from superficial esophageal squamous cell carcinoma.

Kazuhiro Fuchinoue, Tetsuo Nemoto, Hideaki Shimada, Naobumi Tochigi, Yoshinori Igarashi, Satoshi Yajima, Takashi Suzuki, Yoko Oshima, Kazutoshi Shibuya

Abstract read
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In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kazuhiro FuchinoueDepartment of Gastroenterology, School of Medicine, Toho University, Tokyo, Japan.
Tetsuo NemotoDepartment of Pathology, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Hideaki ShimadaDepartment of Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan. hideaki.shimada@med.toho-u.ac.jp.ORCID 0000-0002-1990-8217
Naobumi TochigiDepartment of Surgical Pathology, School of Medicine, Toho University, Tokyo, Japan.
Yoshinori IgarashiDepartment of Gastroenterology, School of Medicine, Toho University, Tokyo, Japan.
Satoshi YajimaDepartment of Gastroenterological Surgery, School of Medicine, Toho University, Tokyo, Japan.
Takashi SuzukiDepartment of Gastroenterological Surgery, School of Medicine, Toho University, Tokyo, Japan.
Yoko OshimaDepartment of Gastroenterological Surgery, School of Medicine, Toho University, Tokyo, Japan.
Kazutoshi ShibuyaDepartment of Surgical Pathology, School of Medicine, Toho University, Tokyo, Japan.
Toho University · JPShowa University Northern Yokohama Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumor budding is known predictors of lymph node metastasis from esophageal squamous cell carcinoma. However, it is not easy to detect such small cell clusters on hematoxylin-eosin (HE) staining. Therefore, we evaluated tumor budding using immunohistochemistry (IHC) for epithelial cell markers.

methodWe analyzed tumor budding in 50 cases of superficial esophageal squamous cell carcinoma. We evaluated the impact of clinicopathological factors and tumor budding to predict lymph node metastasis. A total of 565 tumor sections were assessed using HE staining and IHC for cytokeratin 5/6.

resultsBased on receiver operating characteristic curves, the cut-off values for high-grade tumor budding evaluated using HE staining or IHC were 2 and 11, respectively. High-grade tumor budding evaluated using HE staining (P = 0.007) and IHC (P ≤ 0.001) were significantly correlated with lymph node metastasis. For tumors with pT1a-MM to pT1b-SM1, high-grade tumor budding evaluated using IHC was correlated with lymph node metastasis (P = 0.050).

conclusionsTumor budding was significantly associated with lymph node metastasis. The optimal cut-off values of tumor budding on HE staining and tumor budding on IHC were 2 and 11, respectively. Even though both tumor budding on HE staining and tumor budding on IHC were significantly associated with lymph node metastasis, tumor budding on IHC tend to be more associated with lymph node metastasis.

Indexed as

AgedAged, 80 and overEpithelial CellsEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleHumansImmunohistochemistryKeratinsLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm GradingPredictive Value of TestsRetrospective StudiesKeratinsEsophageal squamous cell carcinomaImmunohistochemistryLymph node metastasisTumor budding

Identifiers

PMID31595396
OpenAlexW2979517871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.