ArticleJournal of neurology2020
Olfactory and gustatory functioning and food preferences of patients with Alzheimer's disease and mild cognitive impairment compared to controls: the NUDAD project.
Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The Association Between Neurocognitive Disorders and Gustatory Dysfunction: A Systematic Review and Meta-Analysis.Neuropsychology review · 2024Pooled it
- Valid olfactory impairment tests can help identify mild cognitive impairment: an updated meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- Association of Odor Identification Ability With Amyloid-β and Tau Burden: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2020Pooled it
- The Effect of Food Odor Exposure on Appetite and Nutritional Intake of Older Adults with Dementia.The journal of nutrition, health & aging · 2022Trial
- Study on Adjuvant Medication for Patients with Mild Cognitive Impairment Based on VR Technology and Health Education.Contrast media & molecular imaging · 2021Trial
- Olfactory and Cognitive Performance Improvement After Oxygen-Ozone Major Autohemotherapy in Mild Cognitive Impairment: A Retrospective Cohort Study.Neurology international · 2026Article
- Nutritional intervention targeting muscle-brain axis in dementia continuum: from mechanisms to practice.Frontiers in nutrition · 2026Review
- Flavour perception in Alzheimer's disease: A systematic review of olfactory and gustatory assessment methods.JAR life · 2026Review
- Olfactory Dysfunction and Cognitive Decline: Are They Related?Current allergy and asthma reports · 2025Review
- Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology.Nature communications · 2025Article
- Insights into salt perception and cognitive impairment among middle-aged and older adults: a scoping review.BMC public health · 2025Article
- Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Association of Olfactory and Gustatory Function with Memory among Community-Dwelling Independent Older Adults.Annals of geriatric medicine and research · 2024Article
- The Value of Subjective Olfactometry as a Predictive Biomarker of Neurodegenerative Diseases: A Systematic Review.Life (Basel, Switzerland) · 2024Review
- The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer's Disease in Subjective Cognitive Decline.Journal of Alzheimer's disease reports · 2023Article
- Association Between Olfactory Dysfunction and Cognitive Impairment in Dementia-Free Older Adults: A Prospective Cohort Study in Taiwan.Journal of Alzheimer's disease : JAD · 2023Article
- Seed-induced Aβ deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer's disease.Molecular psychiatry · 2022Article
- Undetected ophthalmological disorders in Parkinson's disease.Journal of neurology · 2022Observational
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Olfactory Decline in Older Adults with Mild Cognitive Impairment with and without Comorbidities.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Our aim is to compare olfactory and gustatory function and food preferences of patients with Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) with controls. We included 22 patients with MCI, 30 patients with AD and 40 controls and assessed olfactory threshold, odor discrimination and odor identification (Sniffin' Sticks), gustatory functioning (Taste Strips), and food preferences (Macronutrient and Taste Preference Ranking Task). Linear regression analyses were used to study associations of five cognitive domains or AD biomarkers with olfactory functioning. Groups did not differ in olfactory threshold, gustatory function and food preferences. Patients with MCI and AD scored lower on odor discrimination and identification than controls. Poorer memory, but no other cognitive domain, was associated with poorer odor discrimination and odor identification, but not with odor threshold. No associations with AD biomarkers were found. In conclusion, patients with MCI and AD have poorer odor discrimination and identification ability than controls, but similar detection thresholds. This is likely a consequence of poorer memory rather than directly caused by AD pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.