ArticleMedical molecular morphology2020
Mechanism of atopic cataract caused by eosinophil granule major basic protein.
Article in Medical molecular morphology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Lens epithelial cell damage and reduced aquaporin-1 immunoreactivity in liquefied mature cataracts.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Early-onset dead bag syndrome following cataract surgery: a case report with clinical and histopathological findings.BMC ophthalmology · 2026Article
- Association of eosinophil major basic protein with intraocular lens dislocation in atopic dermatitis.Scientific reports · 2025Observational
- Increased risk of cataract surgery in patients with allergic disease: a population based cohort study.Scientific reports · 2022Article
- Morphological comparison between three-dimensional structure of immortalized human lens epithelial cells and Soemmering's ring.Medical molecular morphology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Atopic cataracts develop under the ages of 40 years, after which visual acuity rapidly declines. However, the mechanism underlying the development of atopic cataracts is not yet clear. We focused on the eosinophil granule major basic protein (MBP), which was detected in the aqueous humor of atopic cataracts previously, and which was cytotoxic. Specifically, we investigated its origin in this fluid and its effects on lens epithelial cells (LECs). MBP immunostaining was positive in atopic cataract-derived LECs, but negative in age-related cataract-derived LECs. MBP mRNA was not detected in either type of cataract, but protein was detected in the aqueous humor. Furthermore, the flare values associated with atopic cataracts were higher than those with age-related cataracts. When MBP was purified from eosinophils or recombinant MBP was added to LEC culture medium, cell viability decreased in a concentration-dependent manner, but an MBP antibody neutralized the cytotoxic effect of this protein towards these cells. These results were consistent with the flow of MBP into the aqueous humor from the blood due to a compromised blood-aqueous barrier. Thus, MBP could further penetrate the lens capsule and adhere to LECs, resulting in decreased cell viability and the development of atopic cataracts.
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Registered trials
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