Evidence map›Paper›PMID 31595352›Full record

ArticleIntensive care medicine2019

Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy.

Shannon M Fernando, Daniel I McIsaac, Bram Rochwerg, Sean M Bagshaw, John Muscedere, Laveena Munshi, Niall D Ferguson, Andrew J E Seely, Deborah J Cook, Chintan Dave and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. [Frailty in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026
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  12. Impact of Frailty (Clinical Frailty Scale) on Weaning from Mechanical Ventilation: A Systematic Review and Meta-analysis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shannon M FernandoDivision of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada. sfernando@qmed.ca.ORCID http://orcid.org/0000-0003-4549-4289
Daniel I McIsaacDepartment of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, ON, Canada.
Bram RochwergDivision of Critical Care, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Sean M BagshawDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
John MuscedereDepartment of Critical Care Medicine, Queen's University, Kingston, ON, Canada.
Laveena MunshiInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Niall D FergusonInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Andrew J E SeelyDivision of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Deborah J CookDivision of Critical Care, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Chintan DaveDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Peter TanuseputroSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
Kwadwo KyeremantengDivision of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInvasive mechanical ventilation is a common form of life support provided to critically ill patients. Frailty is an emerging prognostic factor for poor outcome in the Intensive Care Unit (ICU); however, its association with adverse outcomes following invasive mechanical ventilation is unknown. We sought to evaluate the association between frailty, defined by the Clinical Frailty Scale (CFS), and outcomes of ICU patients receiving invasive mechanical ventilation.

methodsWe performed a retrospective analysis (2011-2016) of a prospectively collected registry from two hospitals of consecutive ICU patients ≥ 18 years of age receiving invasive mechanical ventilation. CFS scores were based on recorded pre-admission function at the time of hospital admission. The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of first liberation attempt, and tracheostomy.

resultsWe included 8110 patients, and 2529 (31.2%) had frailty (CFS ≥ 5). Frailty was associated with increased odds of hospital death (adjusted odds ratio [aOR]: 1.24 [95% confidence interval [CI] 1.10-1.40) and discharge to long-term care (aOR 1.21 [95% CI 1.13-1.35]). As compared to patients without frailty, patients with frailty had increased odds of extubation failure (aOR 1.17 [95% CI 1.04-1.37]), hospital death following extubation failure (aOR 1.18 [95% CI 1.07-1.28]), tracheostomy (aOR 1.17 [95% CI 1.01-1.36]), and hospital death following tracheostomy (aOR 1.14 [95% CI 1.03-1.25]).

conclusionsThe presence of frailty among patients receiving mechanical ventilation is associated with increased odds of hospital mortality, discharge to long-term care, extubation failure, and need for tracheostomy.

Indexed as

AdultAgedAged, 80 and overAirway ExtubationCohort StudiesCritical IllnessFemaleFrailtyHospital MortalityHumansMaleMiddle AgedOdds RatioRespiration, ArtificialRespiratory InsufficiencyRetrospective StudiesExtubation failureFrailtyMechanical ventilationTracheostomy

Identifiers

PMID31595352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.