ArticleAging and disease2019
The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination.
Article in Aging and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Brain Extracellular Space: From an Overlooked Dimension to Catalyst of a Novel Neuroscience Paradigm.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- [Dynamic distribution and clearance ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- New Insight into the Mechanism of Neurochemical Imbalance in Multiple Sclerosis: Abnormal Transportation of Brain Extracellular Space.Aging and disease · 2025Article
- Functional Connectivity Encodes Sound Locations by Lateralization Angles.Neuroscience bulletin · 2025Article
- [Ursolic acid improved demyelination and interstitial fluid drainage disorders in schizophrenia mice].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Lateralized brunt of sleep deprivation on white matter injury in a rat model of Alzheimer's disease.GeroScience · 2024Article
- Viscoelastic Property of the Brain Assessed With Magnetic Resonance Elastography and Its Association With Glymphatic System in Neurologically Normal Individuals.Korean journal of radiology · 2023Article
- Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice.Nature communications · 2023Article
- New Insights into Alzheimer's Disease: Novel Pathogenesis, Drug Target and Delivery.Pharmaceutics · 2023Review
- Epidural Pulsation Accelerates the Drainage of Brain Interstitial Fluid.Aging and disease · 2023Article
- Wasteosomes (Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- [Epidural photobiomodulation accelerates the drainage of brain interstitial fluid and its mechanism].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Early changes to the extracellular space in the hippocampus under simulated microgravity conditions.Science China. Life sciences · 2022Article
- Evaluation of the Glymphatic System With Diffusion Tensor Imaging-Along the Perivascular Space in Cancer Pain.Frontiers in neuroscience · 2022Article
- The Alteration of Brain Interstitial Fluid Drainage with Myelination Development.Aging and disease · 2021Article
- The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease.Annals of clinical and translational neurology · 2021Review
- Propofol rather than Isoflurane Accelerates the Interstitial Fluid Drainage in the Deep Rat Brain.International journal of medical sciences · 2021Article
- The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation.Aging and disease · 2020Article
- Brain interstitial fluid drainage and extracellular space affected by inhalational isoflurane: in comparison with intravenous sedative dexmedetomidine and pentobarbital sodium.Science China. Life sciences · 2020Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In searching for the drainage route of the interstitial fluid (ISF) in the deep brain, we discovered a regionalized ISF drainage system as well as a new function of myelin in regulating the drainage. The traced ISF from the caudate nucleus drained to the ipsilateral cortex along myelin fiber tracts, while in the opposite direction, its movement to the adjacent thalamus was completely impeded by a barrier structure, which was identified as the converged, compact myelin fascicle. The regulating and the barrier effects of myelin were unchanged in AQP4-knockout rats but were impaired as the integrity of boundary structure of drainage system was destroyed in a demyelinated rat model. We thus proposed that the brain homeostasis was maintained within each ISF drainage division locally, rather than across the brain as a whole. A new brain division system and a new pathogenic mechanism of demyelination are therefore proposed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.