ArticleThe ISME journal2020
Genomic, transcriptomic, and proteomic insights into the symbiosis of deep-sea tubeworm holobionts.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
- Glass scallop genome reveals key adaptations to deep-sea environments and ectosymbiosis.Nature communications · 2026Article
- Intricate chemosymbiosis in a widespread shallow-water thyasirid clam.Science advances · 2026Article
- Cross-domain cooperation drives nutrient acquisition and metabolism in the bark beetle holobiont.The ISME journal · 2026Article
- DOO: integrated multi-omics resources for deep ocean organisms.Nucleic acids research · 2026Article
- A single-cell plume transcriptome atlas of the cold-seep tubeworm Paraescarpia echinospica.Scientific data · 2025Article
- Deep-Sea Cold Seep Campylobacterota: Diversity, Growth, Metabolic Characteristics, and Nutrient Production.Microorganisms · 2025Article
- Comparative metagenomic analysis reveals the adaptive evolutionary traits of siboglinid tubeworm symbionts.Frontiers in microbiology · 2025Article
- Integrated multi-approaches reveal unique metabolic mechanisms of Vestimentifera to adapt to deep sea.Microbiome · 2024Article
- Single-cell RNA-seq reveals distinct metabolic "microniches" and close host-symbiont interactions in deep-sea chemosynthetic tubeworm.Science advances · 2024Article
- Scallop-bacteria symbiosis from the deep sea reveals strong genomic coupling in the absence of cellular integration.The ISME journal · 2024Article
- Metabolically-versatile Ca. Thiodiazotropha symbionts of the deep-sea lucinid clamISME communications · 2024Article
- Uncovering virulence factors inApplied and environmental microbiology · 2023Article
- Diversifying the concept of model organisms in the age of -omics.Communications biology · 2023Review
- Genomic and transcriptomic analyses illuminate the molecular basis of the unique lifestyle of a tubeworm, Lamellibrachia satsuma.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
- Early genome erosion and internal phage-symbiont-host interaction in the endosymbionts of a cold-seep tubeworm.iScience · 2023Article
- Distinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep-sea annelid worms.Nature communications · 2023Article
- The complete and closed genome of the facultative generalist Candidatus Endoriftia persephone from deep-sea hydrothermal vents.Molecular ecology resources · 2022Article
- Bacteria Associated with Benthic Invertebrates from Extreme Marine Environments: Promising but Underexplored Sources of Biotechnologically Relevant Molecules.Marine drugs · 2022Review
- Complete gammaproteobacterial endosymbiont genome assembly from a seep tubeworm Lamellibrachia satsuma.Journal of microbiology (Seoul, Korea) · 2022Article
- Comparative transcriptomic analysis ofiScience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep-sea hydrothermal vents and methane seeps are often densely populated by animals that host chemosynthetic symbiotic bacteria, but the molecular mechanisms of such host-symbiont relationship remain largely unclear. We characterized the symbiont genome of the seep-living siboglinid Paraescarpia echinospica and compared seven siboglinid-symbiont genomes. Our comparative analyses indicate that seep-living siboglinid endosymbionts have more virulence traits for establishing infections and modulating host-bacterium interaction than the vent-dwelling species, and have a high potential to resist environmental hazards. Metatranscriptome and metaproteome analyses of the Paraescarpia holobiont reveal that the symbiont is highly versatile in its energy use and efficient in carbon fixation. There is close cooperation within the holobiont in production and supply of nutrients, and the symbiont may be able to obtain nutrients from host cells using virulence factors. Moreover, the symbiont is speculated to have evolved strategies to mediate host protective immunity, resulting in weak expression of host innate immunity genes in the trophosome. Overall, our results reveal the interdependence of the tubeworm holobiont through mutual nutrient supply, a pathogen-type regulatory mechanism, and host-symbiont cooperation in energy utilization and nutrient production, which is a key adaptation allowing the tubeworm to thrive in deep-sea chemosynthetic environments.
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