Evidence map›Paper›PMID 31595044›Full record

ReviewProstate cancer and prostatic diseases2020

Lutetium-177 prostate-specific membrane antigen (PSMA) theranostics: practical nuances and intricacies.

Amir Iravani, John Violet, Arun Azad, Michael S Hofman

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Prostate cancer and prostatic diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03511664 (VISION), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03511664 phase3completednot on this map

VISION: An International, Prospective, Open Label, Multicenter, Randomized Phase 3 Study of 177Lu-PSMA-617 in the Treatment of Patients With Progressive PSMA-positive Metastatic Castration-resistant Prostate Cancer (mCRPC)

TypeinterventionalSponsorEndocyteRan2018 to 2023Enrolled861ConditionsProstate CancerArms177Lu-PSMA-617, Best supportive/best standard of care
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Quantitative PSMA PET Biomarkers for Predicting Response toJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Molecules (Basel, Switzerland) · 2025
    Review
  6. Review
  7. Metabolic and imaging phenotypes associated withbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. An Overview of In Vitro Assays ofDiagnostics (Basel, Switzerland) · 2023
    Review
  14. TheranosticFrontiers in oncology · 2023
    Article
  15. Lutetium-177-PSMA-617: A Vision of the Future.Cancer biology & therapy · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Lutetium Lu 177 Vipivotide Tetraxetan: First Approval.Molecular diagnosis & therapy · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amir IravaniMolecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-1273-5835
John VioletRadiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Arun AzadSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.
Michael S HofmanMolecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. Michael.hofman@petermac.org.ORCID http://orcid.org/0000-0001-8622-159X
The University of Melbourne · AUPeter MacCallum Cancer Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theranostic principles utilize a molecular biomarker specific for a tumor target, initially for imaging to assess target expression and, if deemed suitable, for targeted therapy. This presents an exciting opportunity for a highly personalized treatment strategy in the era of precision medicine. Prostate-specific membrane antigen (PSMA) theranostics has attracted increasing attention as a promising targeted treatment in metastatic prostate cancer (PC).

Indexed as

Molecular ImagingMolecular Targeted TherapyTheranostic NanomedicineCombined Modality TherapyDipeptidesDisease ManagementDrug Administration ScheduleFollow-Up StudiesHeterocyclic Compounds, 1-RingHumansLutetiumMaleNeoplasm StagingPatient SelectionPositron Emission Tomography Computed TomographyPrognosisDipeptidesHeterocyclic Compounds, 1-RingLutetiumPluvictoProstate-Specific Antigen

Identifiers

PMID31595044
OpenAlexW2979774200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.