ArticleScientific reports2019
Metabolic output defines Escherichia coli as a health-promoting microbe against intestinal Pseudomonas aeruginosa.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Investigating the infant gut microbiota in developing countries: worldwide metagenomic meta-analysis involving infants living in sub-urban areas of Côte d'Ivoire.Environmental microbiology reports · 2021Pooled it
- Dynamic interaction between Escherichia coli enterotoxins and bacteriocins.The FEBS journal · 2026Article
- Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection.Nature protocols · 2026Review
- Everything is everywhere but Escherichia coli adapts to different niches.The ISME journal · 2026Article
- Adding Guar Gum to High-Fat Diets Ameliorates Fish Growth, Gut Histology, Gut Microbiota Composition, and Intestinal Inflammation in Common Carp.Aquaculture nutrition · 2026Article
- Assessment of gut microbiota in the elderly with sarcopenic obesity: a case-control study.Journal of diabetes and metabolic disorders · 2025Article
- The role of bacterial metabolism in human gut colonization.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Review
- Review
- Food colorant brilliant blue causes persistent functional and structural changes in an in vitro simplified microbiota model system.ISME communications · 2025Article
- Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction.Science advances · 2024Article
- Characteristics of gut microbiota of premature infants in the early postnatal period and their relationship with intraventricular hemorrhage.BMC microbiology · 2024Article
- Functional, Antioxidant, Antibacterial, and Antifungal Activity of Edible Flowers.Antioxidants (Basel, Switzerland) · 2024Article
- Risk factors and molecular epidemiology of intestinal colonization by carbapenem-resistant Gram-negative bacteria in patients with hematological diseases: a multicenter case‒control study.Microbiology spectrum · 2024Article
- GutWomen's health reports (New Rochelle, N.Y.) · 2024Article
- Formate Metabolism in Shigella flexneri and Its Effect on HeLa Cells at Different Stages during the Infectious Process.Microbiology spectrum · 2023Article
- Probiotics: insights and new opportunities forCritical reviews in microbiology · 2023Review
- Article
- Colicins of Escherichia coli Lead to Resistance against the Diarrhea-Causing Pathogen Enterotoxigenic E. coli in Pigs.Microbiology spectrum · 2022Article
- Characterization of Antimicrobial Composite Edible Film Formulated from Fermented Cheese Whey and Cassava Peel Starch.Membranes · 2022Article
- Proteobacteria and Firmicutes Secreted Factors Exert Distinct Effects onMetabolites · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gut microbiota acts as a barrier against intestinal pathogens, but species-specific protection of the host from infection remains relatively unexplored. Although lactobacilli and bifidobacteria produce beneficial lactic and short-chain fatty acids in the mammalian gut, the significance of intestinal Escherichia coli producing these acids is debatable. Taking a Koch's postulates approach in reverse, we define Escherichia coli as health-promoting for naturally colonizing the gut of healthy mice and protecting them against intestinal colonization and concomitant mortality by Pseudomonas aeruginosa. Reintroduction of faecal bacteria and E. coli in antibiotic-treated mice establishes a high titre of E. coli in the host intestine and increases defence against P. aeruginosa colonization and mortality. Strikingly, high sugar concentration favours E. coli fermentation to lactic and acetic acid and inhibits P. aeruginosa growth and virulence in aerobic cultures and in a model of aerobic metabolism in flies, while dietary vegetable fats - not carbohydrates or proteins - favour E. coli fermentation and protect the host in the anaerobic mouse gut. Thus E. coli metabolic output is an important indicator of resistance to infection. Our work may also suggest that the lack of antimicrobial bacterial metabolites in mammalian lungs and wounds allows P. aeruginosa to be a formidable microbe at these sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.