ArticleScientific reports2019
Neural correlates of positive and negative symptoms through the illness course: an fMRI study in early psychosis and chronic schizophrenia.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses.Molecular psychiatry · 2023Pooled it
- Restoring Course as a Core Diagnostic Element of Psychotic Disorders.Schizophrenia bulletin · 2025Review
- Multimodal biological profiles of symptom-based subgroups in recent-onset psychosis.Research square · 2025Article
- Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting-State fMRI Study Using Co-Activation Pattern Analysis.Human brain mapping · 2025Article
- Comparison of Negative Symptom Network Structures Between Patients With Early and Chronic Schizophrenia: A Network and Exploratory Graph Analysis.Schizophrenia bulletin · 2025Article
- Connectome-based predictive modeling of early and chronic psychosis symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Negative Schizotypy Associated With Weaker Intersubject Correlation in Dynamic Functional Connectivity During Empathic Accuracy Task.Schizophrenia bulletin · 2025Article
- Diagnosis of Schizophrenia and Its Subtypes Using MRI and Machine Learning.Brain and behavior · 2025Article
- Psychomotor slowing in schizophrenia is associated with aberrant postural control.Schizophrenia (Heidelberg, Germany) · 2024Article
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry.NeuroImage. Clinical · 2024Article
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- Resting-state perfusion in motor and fronto-limbic areas is linked to diminished expression of emotion and speech in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Dysconnection and cognition in schizophrenia: A spectral dynamic causal modeling study.Human brain mapping · 2023Article
- Opposite effects of positive and negative symptoms on resting-state brain networks in schizophrenia.Communications biology · 2023Article
- Violent behavior and the network properties of psychopathological symptoms and real-life functioning in patients with schizophrenia.Frontiers in psychiatry · 2023Article
- Article
- Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.Schizophrenia (Heidelberg, Germany) · 2022Review
- Positive and negative syndrome scale in forensic patients with schizophrenia spectrum disorders: a systematic review and meta-analysis.Annals of general psychiatry · 2022Review
- Abnormal functional connectivity of the striatum in first-episode drug-naive early-onset Schizophrenia.Brain and behavior · 2022Article
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Abstract
Psychotic illness is associated with cognitive control deficits and abnormal recruitment of neural circuits subserving cognitive control. It is unclear to what extent this dysfunction underlies the development and/or maintenance of positive and negative symptoms typically observed in schizophrenia. In this study we compared fMRI activation on a standard Stroop task and its relationship with positive and negative symptoms in early psychosis (EP, N = 88) and chronic schizophrenia (CHR-SZ, N = 38) patients. CHR-SZ patients showed reduced frontal, striatal, and parietal activation across incongruent and congruent trials compared to EP patients. Higher positive symptom severity was associated with reduced activation across both trial types in supplementary motor area (SMA), middle temporal gyrus and cerebellum in EP, but not CHR-SZ patients. Higher negative symptom severity was associated with reduced cerebellar activation in EP, but not in CHR-SZ patients. A negative correlation between negative symptoms and activation in SMA and precentral gyrus was observed in EP patients and in CHR-SZ patients. The results suggest that the neural substrate of positive symptoms changes with illness chronicity, and that cognitive control related neural circuits may be most relevant in the initial development phase of positive symptoms. These findings also highlight a changing role for the cerebellum in the development and later maintenance of both positive and negative symptoms.
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