ArticleScientific reports2019
Sites of persistence of Fusobacterium necrophorum and Dichelobacter nodosus: a paradigm shift in understanding the epidemiology of footrot in sheep.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Social Structure of Sheep Flocks at Points of the Production Cycle and Relationship to Disease Spread, Using a Simulated Epidemic of Footrot.Animals : an open access journal from MDPI · 2026Article
- Variation in the early-life interdigital skin microbiota of lambs in a commercial sheep flock.Frontiers in veterinary science · 2026Article
- Bacterial community analysis of treponeme-associated hoof disease in free-ranging elk (Applied and environmental microbiology · 2025Article
- Ovine lameness in Ireland: a survey-based investigation of farmer reported prevalence, recognition, and treatment of lameness conditions.Irish veterinary journal · 2025Article
- Factors associated with ovine footrot lesions in Uruguayan flocks: a cross-sectional study.Frontiers in veterinary science · 2025Article
- Histopathological and radiographic characterization of the lesions of pododermatitis in sheep: support for the establishment of the foot injuries degree and its prognosis.Frontiers in veterinary science · 2025Article
- Longitudinal assessment of the prevalence ofFrontiers in microbiology · 2025Article
- Lameness in Adult Sheep and Goats in Greece: Prevalence, Predictors, Treatment, Importance for Farmers.Animals : an open access journal from MDPI · 2024Article
- Footbathing and Foot Trimming, and No Quarantine: Risks for High Prevalence of Lameness in a Random Sample of 269 Sheep Flocks in England, 2022.Animals : an open access journal from MDPI · 2024Article
- Molecular Diagnosis of Footrot and Contagious Ovine Digital Dermatitis in Small Ruminants in the Iberian Peninsula.Animals : an open access journal from MDPI · 2024Article
- Characterization of Three New Outer Membrane Adhesion Proteins inMicroorganisms · 2023Article
- Field Study on the Prevalence of Ovine Footrot, Contagious Ovine Digital Dermatitis, and Their Associated Bacterial Species in Swedish Sheep Flocks.Pathogens (Basel, Switzerland) · 2023Article
- Outer-Membrane Vesicles ofMicroorganisms · 2023Article
- The prevalence, virulence, and serogroups ofVeterinary world · 2023Article
- Genome-wide association with footrot in hair and wool sheep.Frontiers in genetics · 2023Article
- NF-κB signaling pathway mechanism in cow intertoe skin inflammation caused byFrontiers in cellular and infection microbiology · 2023Article
- Natural Mycoplasma Infection Reduces Expression of Pro-Inflammatory Cytokines in Response to Ovine Footrot Pathogens.Animals : an open access journal from MDPI · 2022Article
- Risk factors associated with the infection of sheep with Dichelobacter nodosus.Scientific reports · 2022Article
- Differences in composition of interdigital skin microbiota predict sheep and feet that develop footrot.Scientific reports · 2022Article
- Prevalence of bacterial species associated with ovine footrot and contagious ovine digital dermatitis in Swedish slaughter lambs.Acta veterinaria Scandinavica · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sites of persistence of bacterial pathogens contribute to disease dynamics of bacterial diseases. Footrot is a globally important bacterial disease that reduces health and productivity of sheep. It is caused by Dichelobacter nodosus, a pathogen apparently highly specialised for feet, while Fusobacterium necrophorum, a secondary pathogen in footrot is reportedly ubiquitous on pasture. Two prospective longitudinal studies were conducted to investigate the persistence of D. nodosus and F. necrophorum in sheep feet, mouths and faeces, and in soil. Molecular tools were used to detect species, strains and communities. In contrast to the existing paradigm, F. necrophorum persisted on footrot diseased feet, and in mouths and faeces; different strains were detected in feet and mouths. D. nodosus persisted in soil and on diseased, but not healthy, feet; similar strains were detected on both healthy and diseased feet of diseased sheep. We conclude that D. nodosus and F. necrophorum depend on sheep for persistence but use different strategies to persist and spread between sheep within and between flocks. Elimination of F. necrophorum would be challenging due to faecal shedding. In contrast D. nodosus could be eliminated if all footrot-affected sheep were removed and fade out of D. nodosus occurred in the environment before re-infection of a foot.
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