ArticleScientific reports2019
Choline supported poly(ionic liquid) graft copolymers as novel delivery systems of anionic pharmaceuticals for anti-inflammatory and anti-coagulant therapy.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Graft Polymers Derived from Pharmaceutically Active Choline-Based Ionic Liquid Monomers: Dual Incorporation of Ampicillin and Cloxacillin.International journal of molecular sciences · 2025Article
- Management of Patients Receiving Anticoagulation Therapy in Dental Practice: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Photoresponse of new azo pyridine functionalized poly(2-hydroxyethyl methacrylate-co-methyl methacrylate).Scientific reports · 2024Article
- Ionic Liquid-Based Polymer Matrices for Single and Dual Drug Delivery: Impact of Structural Topology on Characteristics and In Vitro Delivery Efficiency.International journal of molecular sciences · 2024Article
- Characterization of Graft Copolymers Synthesized fromPharmaceutics · 2023Article
- Self-Assembling Polymers withPharmaceuticals (Basel, Switzerland) · 2023Article
- Synthesis and Characterization of Linear Copolymers Based on Pharmaceutically Functionalized Monomeric Choline Ionic Liquid for Delivery ofPharmaceutics · 2023Article
- Pharmaceutical Functionalization of Monomeric Ionic Liquid for the Preparation of Ionic Graft Polymer Conjugates.International journal of molecular sciences · 2022Article
- Mimic Nature Using Chemotaxis of Ionic Liquid Microdroplets for Drug Delivery Purposes.Molecules (Basel, Switzerland) · 2022Review
- Biological In Vitro Evaluation of PIL Graft Conjugates: Cytotoxicity Characteristics.International journal of molecular sciences · 2021Article
- Linear Copolymers Based on Choline Ionic Liquid Carrying Anti-Tuberculosis Drugs: Influence of Anion Type on Physicochemical Properties and Drug Release.International journal of molecular sciences · 2020Article
- PEG Graft Polymer Carriers of Antioxidants: In Vitro Evaluation for Transdermal Delivery.Pharmaceutics · 2020Article
- Synthesis and Characterization of Ionic Graft Copolymers: Introduction and In Vitro Release of Antibacterial Drug by Anion Exchange.Polymers · 2020Article
- Ionic Polymethacrylate Based Delivery Systems: Effect of Carrier Topology and Drug Loading.Pharmaceutics · 2019Review
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5 authors.
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Abstract
New type of carriers based on grafted poly(ionic liquid)s was designed for delivery of ionically attached salicylates (Sal). Choline derived ionic liquid monomeric units were successfully introduced with various content in the side chains by the controlled radical polymerization. Properly high amounts of ionic pharmaceutics in the polymer systems were achieved by the well-fitted length and grafting degree of the side chains. In aqueous solution the graft copolymers were self-assembled into the spherical superstructures with sizes up to 73 nm. Delivery studies showed "burst" release within 4 h, after that it was slower yielding ~70% of released drug within 80 h. Proposed nanocarriers supported low toxicity against human cells (NHDF and BEAS-2B), anti-inflammation activity evaluated with the use of pro-inflammatory interleukins (IL-6 and IL-8) and antibacterial activities towards E. coli. Adjustment of ionic drug content by structural parameters of graft copolymers, including grafting degree and graft length, are advantageous to tailor nanocarriers with self-assembly properties in aqueous media. Effective release process by ionic exchange and biological activity with low toxicity are promising for further development of this type of drug delivery (DDS).
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